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Comment
. 2022 Dec;43(12):1001-1003.
doi: 10.1016/j.tips.2022.08.004. Epub 2022 Aug 30.

A pharmacological strategy to recapitulate exercise-induced antitumoral immunity

Amélie Rébillard  1 , Jacques A Nunès  2 , Alice Carrier  3
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Comment

A pharmacological strategy to recapitulate exercise-induced antitumoral immunity

Amélie Rébillard et al. Trends Pharmacol Sci. 2022 Dec.
Free article

Abstract

The antitumor activity of exercise by means of enhanced immune activation is documented, but better identification of the underlying mechanisms is required to develop new therapeutic strategies. Recent work from the Dr Bar-Sagi group reveals that exercise engages IL-15 signaling and pharmacological activation of the IL-15/IL-15R axis mimics the exercise-driven immune cell-mediated cytotoxicity in pancreatic cancer.

Keywords: IL-15 superagonist; immunology; pancreatic cancer; physical activity.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interests.

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