Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Aug 23:2022:3022672.
doi: 10.1155/2022/3022672. eCollection 2022.

Transepithelial Photorefractive Keratectomy Compared to Conventional Photorefractive Keratectomy: A Meta-Analysis

Tariq Alasbali  1
Affiliations
Review

Transepithelial Photorefractive Keratectomy Compared to Conventional Photorefractive Keratectomy: A Meta-Analysis

Tariq Alasbali. J Ophthalmol. .

Abstract

This meta-analysis review compares the primary and secondary outcomes of transepithelial photorefractive keratectomy (TPRK) to the conventional photorefractive keratectomy (PRK), in terms of efficacy, predictability, safety, and patient perspectives. A total of 1711 eyes with PRK (811 eyes) and TPRK (900 eyes) from 12 studies were included through bibliographic searches. The main outcomes were efficacy, predictability, and safety parameters, and the secondary outcomes included visual and patient-reported parameters. The effect measures were weighted mean differences with 95% confidence intervals (CI) which were derived from the random-effects model of the meta-analysis to account for possible heterogeneity. TPRK procedure presents a comparable status in the main outcome and a very dominant significance in all the secondary outcomes in this meta-analysis. This study updates the evidence of the accuracy of TPRK procedure for surgical correction of all refractive errors and was deemed safer with less surgical time required and an early healing time.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram study selection process.
Figure 2
Figure 2
Risk of bias summary about the methodological quality of studies included using the Cochrane risk of bias tool. Symbols show low risk of bias shown as “+”, unclear risk of bias, or other bias shown as a blank space, or high risk of bias shown as “−”.
Figure 3
Figure 3
Forest plot of postoperative UDVA comparison between TPRK and the conventional PRK.
Figure 4
Figure 4
Comparison of the forest plot of the postoperative SE between TPRK and the conventional PRK.
Figure 5
Figure 5
Comparison of the forest plot of postoperative BCDVA between TPRK and the conventional PRK.
Figure 6
Figure 6
Comparison of the forest plot of postoperative corneal haze dichotomous outcome between TPRK and the conventional PRK.
Figure 7
Figure 7
Comparison of the forest plot of the secondary outcomes in the study between TPRK and the conventional PRK.
See this image and copyright information in PMC

References

    1. Sharma I. P., Lepcha N. T., Lhamo T., et al. Visual impairment and refractive error in school children in Bhutan: the findings from the Bhutan School Sight Survey (BSSS 2019) PLoS One . 2020;15(9) doi: 10.1371/journal.pone.0239117.e0239117 - DOI - PMC - PubMed
    1. Jabbour S., Bower K. S. Refractive surgery in the US in 2021. JAMA . 2021;326(1):p. 77. doi: 10.1001/jama.2020.20245. - DOI - PubMed
    1. Xie Y., Zhao L., Yang X., et al. Screening candidates for refractive surgery with corneal tomographic–based deep learning. JAMA Ophthalmol . 2020;138(5):p. 519. doi: 10.1001/jamaophthalmol.2020.0507. - DOI - PMC - PubMed
    1. Murueta-Goyena A., Cañadas P. Visual outcomes and management after corneal refractive surgery: a review. Journal of Optometry . 2018;11(2):121–129. doi: 10.1016/j.optom.2017.09.002. - DOI - PMC - PubMed
    1. Ang M., Gatinel D., Reinstein D. Z., Mertens E., Alió del Barrio J. L., Alió J. L. Refractive surgery beyond 2020. Eye . 2020;35(2):362–382. doi: 10.1038/s41433-020-1096-5. - DOI - PMC - PubMed

LinkOut - more resources