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. 2022 Aug 16:13:924414.
doi: 10.3389/fendo.2022.924414. eCollection 2022.

Distant organ metastasis patterns and prognosis of neuroendocrine cervical carcinoma: a population-based retrospective study

Qing Li  1   2 , Jie Yu  1   3 , Hanjie Yi  1   2 , Qiongyu Lan  1   2
Affiliations

Distant organ metastasis patterns and prognosis of neuroendocrine cervical carcinoma: a population-based retrospective study

Qing Li et al. Front Endocrinol (Lausanne). .

Abstract

Background: Neuroendocrine carcinoma of the cervix (NECC) is a rare pathological form of cervical cancer. The prognosis of NECC with distant organ metastases is unclear. In our study, the patterns and prognosis of distant organ metastasis of NECC were investigated.

Methods: Data were obtained from the surveillance epidemiology and end results (SEER) database from 2000 to 2018. Cox regression, Kaplan-Meier and log-rank analyses were conducted.

Results: NECC was prone to single and multi-site metastases. The median overall survival (OS) was greatly decreased in patients with distant metastasis (P < 0.0001). Other characteristics such as age ≥60 years, poorer grade, higher T stage, those without surgery, no radiotherapy, and no chemotherapy were predictors of poor prognosis.

Conclusions: Metastasis is an independent prognostic factor for patients with NECC. Surgery, radiotherapy, and chemotherapy give an overall survival advantage for patients with distant organ metastases.

Keywords: SEER database; metastasis; neuroendocrine cervical carcinoma; prognosis; survival.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the neuroendocrine cervical cancer patient’s selection.
Figure 2
Figure 2
Kaplan-Meier curves of the overall survival in NECC cancer stratified by (A) metastasis (M0: no metastasis, M1 metastasis) (P < 0.0001) and (B) different sites of metastasis (M bone, M brain, M liver, M lung, M >1 site) (P > 0.05).
Figure 3
Figure 3
Kaplan-Meier curves of the overall survival in NECC with no metastasis or metastasis when stratified by treatment. (A) Surgery in no metastasis patients (P < 0.0001); (B) Surgery in metastasis patients (P < 0.0001) (C) Radiotherapy in no metastasis patients (P > 0.05), (D) Radiotherapy in metastasis patients (P < 0.05), (E) Chemotherapy in no metastasis patients (P < 0.001) (F) Chemotherapy in metastasis patients (P < 0.0001).
See this image and copyright information in PMC

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