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. 2022 Jul 3;56(9):1565-1571.
doi: 10.1007/s43465-022-00686-5. eCollection 2022 Sep.

Efficacy of sCOMP and sCTX-I in Diagnosis of Knee Osteoarthritis

Altaf Hussain  1 , Chetan Verma  2 , Lal Shrikant Kaushik  2 , Sudhir Singh  2
Affiliations

Efficacy of sCOMP and sCTX-I in Diagnosis of Knee Osteoarthritis

Altaf Hussain et al. Indian J Orthop. .

Abstract

Objective: The aim of this study was to evaluate the efficacy of serum cartilage oligomeric matrix protein (sCOMP) and serum C-terminal cross-linked telopeptide of type I collagen (sCTX-I) in identifying disease severity in knee osteoarthritis (KOA) cases.

Methods: A total of 150 individuals (100 cases and 50 controls) were recruited. They were assessed clinically and radiologically with WOMAC score and knee radiographs respectively, while biochemical assessment was done by serum COMP and serum CTX-I level.

Results: There were significant differences in serum levels between healthy individuals and KOA patients of both, sCOMP (01.16 ± 0.39 vs 17.38 ± 4.99 U/L; p = 0.01) and sCTX-I (0.35 ± 0.14 vs 4.59 ± 1.69; p = 0.02). There was a statistically significant difference between serum levels of CTX-I between K-L grade I and grade II (4.59 ± 1.69 vs 4.60 ± 1.17 ng/mL; p = 0.03) but no significant difference was seen in the sCOMP levels between K-L grade I and grade II (14.60 ± 6.47 vs 17.47 ± 4.99 U/L; p = 0.14).

Conclusion: Our findings reveal that both sCOMP and sCTX-I are very effective in distinguishing between healthy adults and those affected by KOA. Only CTX-I was also able to distinguish between K-L grades I and II, while sCOMP failed. Further, use of these two biomarkers to differentiate between K-L grade II, III and IV is limited and lacks sufficient discriminating power, hence not recommended.

Keywords: Knee osteoarthritis; K–L grading; WOMAC; sCOMP; sCTX-I.

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Conflict of interest statement

Conflict of InterestThe authors declare that there is no conflict of interest regarding the publication of this article.

References

    1. Heidari B. Knee osteoarthritis diagnosis, treatment and associated factors of progression: part II. Caspian Journal of Internal Medicine. 2011;2(3):249–255. - PMC - PubMed
    1. Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: A health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. The Journal of Rheumatology. 1988;15(12):1833–1840. - PubMed
    1. Kellgren JH, Lawrence J. Radiological assessment of osteo-arthrosis. Annals of the Rheumatic Diseases. 1957;16(4):494. doi: 10.1136/ard.16.4.494. - DOI - PMC - PubMed
    1. Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clinics in Geriatric Medicine. 2010;26(3):355–369. doi: 10.1016/j.cger.2010.03.001. - DOI - PMC - PubMed
    1. Safiri S, Kolahi AA, Smith E, Hill C, Bettampadi D, Mansournia MA, Hoy D, Ashrafi-Asgarabad A, Sepidarkish M, Almasi-Hashiani A, Collins G, Kaufman J, Qorbani M, Moradi-Lakeh M, Woolf AD, Guillemin F, March L, Cross M. Global, regional and national burden of osteoarthritis 1990–2017: A systematic analysis of the Global Burden of Disease Study 2017. Annals of the Rheumatic Diseases. 2020;79(6):819–828. doi: 10.1136/annrheumdis-2019-216515. - DOI - PubMed

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