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. 2023 Feb 14;116(1):47-56.
doi: 10.1093/qjmed/hcac202.

Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection

A Mukherjee  1 , G Kumar  1 , A Turuk  1 , A Bhalla  2 , T C Bingi  3 , P Bhardwaj  4 , T D Baruah  5 , S Mukherjee  6 , A Talukdar  7 , Y Ray  8 , M John  9 , J R Khambholja  10 , A H Patel  11 , S Bhuniya  12 , R Joshi  13 , G R Menon  14 , D Sahu  14 , V V Rao  14 , B Bhargava  1 , S Panda  1 ; NCRC Study Team
Collaborators, Affiliations

Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection

A Mukherjee et al. QJM. .

Abstract

Objectives: This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC).

Methods: NCRC is an on-going data collection platform operational in 42 hospitals across India. Data of hospitalized COVID-19 patients enrolled in NCRC between 1st September 2020 to 26th October 2021 were examined.

Results: Analysis of 29 509 hospitalized, adult COVID-19 patients [mean (SD) age: 51.1 (16.2) year; male: 18 752 (63.6%)] showed that 15 678 (53.1%) had at least one comorbidity. Among 25 715 (87.1%) symptomatic patients, fever was the commonest symptom (72.3%) followed by shortness of breath (48.9%) and dry cough (45.5%). In-hospital mortality was 14.5% (n = 3957). Adjusted odds of dying were significantly higher in age group ≥60 years, males, with diabetes, chronic kidney diseases, chronic liver disease, malignancy and tuberculosis, presenting with dyspnoea and neurological symptoms. WHO ordinal scale 4 or above at admission carried the highest odds of dying [5.6 (95% CI: 4.6-7.0)]. Patients receiving one [OR: 0.5 (95% CI: 0.4-0.7)] or two doses of anti-SARS CoV-2 vaccine [OR: 0.4 (95% CI: 0.3-0.7)] were protected from in-hospital mortality.

Conclusions: WHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients. Anti-SARS-CoV2 vaccination provides significant protection against mortality.

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