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Comment
. 2022 Sep 1;48(9):932-936.
doi: 10.1097/DSS.0000000000003532. Epub 2022 Jul 1.

Enhanced Uptake and Retention of 0.03% Bimatoprost, 0.5% 5-Fluorouracil, and 5% Minoxidil After 1,550-nm or 1,927-nm Nonablative Laser Pretreatment

Jordan V Wang  1 , Paul M Friedman  1   2 , Samantha Agron  3 , Adarsh Konda  4 , Catherine Parker  5 , Roy G Geronemus  1
Affiliations
Comment

Enhanced Uptake and Retention of 0.03% Bimatoprost, 0.5% 5-Fluorouracil, and 5% Minoxidil After 1,550-nm or 1,927-nm Nonablative Laser Pretreatment

Jordan V Wang et al. Dermatol Surg. .

Abstract

Background: Laser pretreatment with cosmeceutical topicals is growing in popularity. However, lasers may also enhance the uptake of medical topicals that treat dermatologic conditions, such as vitiligo, alopecia, and cancerous and precancerous lesions. Permeation of these topicals must be quantified to optimize treatment protocols.

Objective: To analyze transdermal uptake of 3 topicals after nonablative fractional 1,550-nm erbium-doped glass or 1,927-nm thulium fiber laser pretreatment.

Methods and materials: Human donor tissue was pretreated with a nonablative fractional 1,550-nm erbium-doped glass or 1,927-nm thulium fiber laser followed by application of 0.03% bimatoprost, 0.5% 5-fluorouracil, or 5% minoxidil. Permeation and retention were measured over 24 hours (bimatoprost and 5-fluorouracil) or 90 minutes (minoxidil), and uptake was calculated.

Results: Pretreatment with 1,927-nm thulium laser (500 MTZ/cm2; 5 mJ; 5 W) enhanced uptake and retention of bimatoprost versus untreated control at 24 hours post-treatment. Pretreatment with 1,550-nm erbium-doped glass laser (2,000 MTZ/cm2; 10 mJ; 30 W) enhanced permeation, uptake, and retention of 5-fluorouracil at 24 hours post-treatment and enhanced permeation and uptake of minoxidil at 90 minutes post-treatment.

Conclusion: Nonablative laser pretreatment may enhance topical treatment of dermatologic conditions. Device settings must be optimized to maximize topical permeation while minimizing laser-associated thermal side effects.

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Comment on

  • Bimatoprost in Dermatology.
    Jha AK, Sarkar R, Udayan UK, Roy PK, Jha AK, Chaudhary RKP. Jha AK, et al. Indian Dermatol Online J. 2018 May-Jun;9(3):224-228. doi: 10.4103/idoj.IDOJ_62_16. Indian Dermatol Online J. 2018. PMID: 29854658 Free PMC article.

References

    1. Searle T, Ali FR, Al-Niaimi F. Lessons learned from the first decade of laser-assisted drug delivery. Dermatol Ther (Heidelb) 2021;11:93–104.
    1. Friedman PM, Polder KD, Sodha P, Geronemus RG. The 1440 nm and 1927 nm nonablative fractional diode laser: current trends and future directions. J Drugs Dermatol 2020;19:s3–11.
    1. Machado BHB, Frame J, Zhang J, Najlah M. Comparative study on the outcome of periorbital wrinkles treated with laser-assisted delivery of vitamin C or vitamin C plus growth factors: a randomized, double-blind, clinical trial. Aesthet Plast Surg 2021;45:1020–32.
    1. Farkas JP, Hoopman JE, Kenkel JM. Five parameters you must understand to master control of your laser/light-based devices. Aesthet Surg J 2013;33:1059–64.
    1. Wang JV, Mehrabi JN, Zachary CB, Geronemus RG. Evaluation of device-based cutaneous channels using optical coherence tomography: impact for topical drug delivery. Dermatol Surg 2022;48:120–5.

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