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. 2023 Jan;28(1):29-36.
doi: 10.1111/resp.14349. Epub 2022 Aug 23.

Global, regional and national burden of chronic obstructive pulmonary disease over a 30-year period: Estimates from the 1990 to 2019 Global Burden of Disease Study

Hao-Yang Li  1 , Teng-Yu Gao  1 , Wei Fang  1 , Chen-Yang Xian-Yu  1 , Nian-Jia Deng  1 , Chao Zhang  1 , Yu-Ming Niu  2
Affiliations

Global, regional and national burden of chronic obstructive pulmonary disease over a 30-year period: Estimates from the 1990 to 2019 Global Burden of Disease Study

Hao-Yang Li et al. Respirology. 2023 Jan.

Abstract

Background and objective: Chronic obstructive pulmonary disease (COPD) is the most prevalent chronic respiratory disease. This study investigated the global, regional and country burden of COPD based on gender, age and socio-demographic indices (SDIs) in the last 30-year period from 1990 to 2019.

Methods: The COPD data, including incidence, mortality and disability-adjusted life years (DALYs), were obtained from the 2019 Global Burden of Disease Study. If age-standardized incidence rate (ASIR) or death rate (ASDR) remains almost constant or decreases, the number of cases will still increase as the global population increases substantially. Estimated annual percentage change (EAPC) was calculated to assess incidence, mortality and DALY trends.

Results: The incidence of COPD increased by 85.89% from 8,722,966 cases in 1990 to 16,214,828 cases in 2019, and the ASIR decreased from 216.48/100,000 persons in 1990 (95%UI, 204.56-227.33) to 200.49 per 100,000 persons (95%UI, 188.63-212.57) in 2019. The ASIR increased (EAPC = 0.05, 95%CI, 0.01-0.10) in the low SDI region, was stable in the high SDI region, and fell in the other three SDI regions. Men had a higher ASIR than women over the past 30 years, and there were differences in the incidence rates for different age groups. Male mortality and DALYs were higher than female mortality. ASDR decreased by 2.13% (95%CI, -2.23% to -2.02%) per year and the annual age-standardized DALY rate decreased by 1.97% (95%CI, -2.05% to -1.89%).

Conclusions: The ASIR, ASDR and age-standardized DALY rate of COPD declined overall in the last 30 years, and were highest in the low-middle SDI region.

Keywords: chronic obstructive pulmonary disease; disability adjusted life-years; global burden of disease; incidence; mortality.

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Conflict of interest statement

None declared.

Figures

FIGURE 1
FIGURE 1
The change trends of age‐standardized incidence, death and DALY rate among different SDI quintiles. (A) Age‐standardized both incidence. (B) Age‐standardized female incidence. (C) Age‐standardized male incidence. (D) Age‐standardized both death rate. (E) Age‐standardized female death rate. (F) Age‐standardized male death rate. (G) Age‐standardized both DALY rate. (H) Age‐standardized female DALY rate. (I) Age‐standardized male DALY rate
FIGURE 2
FIGURE 2
The ratio of male to female incidence among different age groups in 2019. (A) Global. (B) High SDI. (C) High‐middle SDI. (D) Middle SDI. (E) Middle‐low SDI. (F) Low SDI. SDI, socio‐demographic index.
FIGURE 3
FIGURE 3
Distribution of different ages in chronic obstructive pulmonary disease incidence/death cases by region. (A) Incidence in 1990. (B) Incidence in 2019. (C) Death rate in 1990. (D) Death rate in 2019
See this image and copyright information in PMC

Comment in

References

    1. World Health Organization . Chronic obstructive pulmonary disease. 2021. [21 Jun 2021] Available from: https://wwwwhoint/zh/news-room/fact-sheets/detail/chronic-obstructive-pu...
    1. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007;176:532–55. - PubMed
    1. GBD 2016 Causes of Death Collaborators . Global, regional, and national age‐sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390:1151–210. - PMC - PubMed
    1. López‐Campos JL, Tan W, Soriano JB. Global burden of COPD. Respirology. 2016;21:14–23. - PubMed
    1. Fernández E, López MJ, Gallus S, Semple S, Clancy L, Behrakis P, et al. Tackling second‐hand exposure to tobacco smoke and aerosols of electronic cigarettes: the TackSHS project protocol. Gac Sanit. 2020;34:77–82. - PubMed