A SPARC-ling link to inflammaging

Jonathan S Maltzman^{1

2}

Affiliations

¹ Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
² Geriatric Research and Education and Clinical Center, Veterans Administration Palo Alto Health Care System, Palo Alto, CA, USA.

Jonathan S Maltzman. Sci Immunol. 2022.

. 2022 Sep 2;7(75):eade5698.

doi: 10.1126/sciimmunol.ade5698. Epub 2022 Sep 2.

Jonathan S Maltzman^{1

2}

¹ Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
² Geriatric Research and Education and Clinical Center, Veterans Administration Palo Alto Health Care System, Palo Alto, CA, USA.

Abstract

Adipocyte derived SPARC induces pro-inflammatory changes to macrophages, leading to aging that can be reduced by caloric restriction.