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Comment
. 2022 Sep 12;40(9):911-913.
doi: 10.1016/j.ccell.2022.08.017. Epub 2022 Sep 1.

ctDNA-guided adjuvant chemotherapy for colorectal cancer-ready for prime time?

Claus L Andersen  1 , Ellen Heitzer  2
Affiliations
Free article
Comment

ctDNA-guided adjuvant chemotherapy for colorectal cancer-ready for prime time?

Claus L Andersen et al. Cancer Cell. .
Free article

Abstract

In stage II colorectal cancer, adjuvant chemotherapy is controversial, and overtreatment is substantial due to suboptimal risk stratification. In a recent New England Journal of Medicine article reporting from a prospective randomized phase II trial, Tie and colleagues demonstrate how ctDNA-guided risk-stratification reduces the use of adjuvant chemotherapy without compromising recurrence risk.

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Conflict of interest statement

Declaration of interests C.L.A. declares research funding from C2i Genomics, Delfi Diagnostics, and Natera Inc. E.H. has an unrelated sponsored research agreement with Servier and received funding from Freenome, PreAnalytiX, Illumina, and Roche and honoraria for advisory boards from Roche.

Comment on

  • Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer.
    Tie J, Cohen JD, Lahouel K, Lo SN, Wang Y, Kosmider S, Wong R, Shapiro J, Lee M, Harris S, Khattak A, Burge M, Harris M, Lynam J, Nott L, Day F, Hayes T, McLachlan SA, Lee B, Ptak J, Silliman N, Dobbyn L, Popoli M, Hruban R, Lennon AM, Papadopoulos N, Kinzler KW, Vogelstein B, Tomasetti C, Gibbs P; DYNAMIC Investigators. Tie J, et al. N Engl J Med. 2022 Jun 16;386(24):2261-2272. doi: 10.1056/NEJMoa2200075. Epub 2022 Jun 4. N Engl J Med. 2022. PMID: 35657320 Free PMC article. Clinical Trial.

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