CHARGE-AF: A Useful Score For Atrial Fibrillation Prediction?

Abstract

Atrial fibrillation (AF) is the commonest arrhythmia in clinical practice and is associated with increased morbidity and mortality. Various predictive scores for new-onset AF have been proposed, but so far, none have been widely used in clinical practice. CHARGE-AF score was developed from a pooled diverse population from three large cohorts (Atherosclerosis Risk in Communities study, Cardiovascular Health Study and Framingham Heart Study). A simple 5-year predictive model includes the variables of age, race, height, weight, systolic and diastolic blood pressure, current smoking, use of antihypertensive medication, diabetes mellitus, history of myocardial infarction and heart failure. Recent studies report that the CHARGE-AF score has good discrimination for incident AF and seems to be a promising prediction model for this arrhythmia. New screening tools (smartphone apps, smartwatches) are rapidly developing for AF detection. Therefore, the wide application of the CHARGE-AF score in clinical practice and the upcoming usage of mobile health technologies and smartwatches may result in better AF prediction and adequate stroke prevention, especially in high-risk patients.

Keywords: Atrial fibrillation; CHARGE-AF score; FHS-AF; cardiovascular; myocardial infarction; prediction.

Fig. (1)

Discriminative performance. Squares represent the AUROC curves in the analysis of all 2.5M participants and diamonds in 1.2M participants with CHA2DS2-VASc of two or more. The vertical bars represent the 95% CIs. The AUROC curves are based on the regression equation in 12 prediction models [15].