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. 2022 Sep 3;8(1):97.
doi: 10.1186/s40795-022-00582-z.

Effect of fruit smoothie supplementation on psychological distress among people with substance use disorders receiving opioid agonist therapy: protocol for a randomised controlled trial (FruktBAR)

Lars T Fadnes  1   2 , Einar Furulund  3   4   5 , Karl Trygve Druckrey-Fiskaaen  3   4 , Tesfaye Madebo  3   6 , Jørn Henrik Vold  3   4   7 , Maria Olsvold  3 , Marianne Cook Pierron  3 , Siv-Elin Leirvåg Carlsen  3 , Rune Blomhoff  8   9 , Torgeir Gilje Lid  5   10 ; ATLAS4LAR Study Group
Collaborators, Affiliations

Effect of fruit smoothie supplementation on psychological distress among people with substance use disorders receiving opioid agonist therapy: protocol for a randomised controlled trial (FruktBAR)

Lars T Fadnes et al. BMC Nutr. .

Abstract

Background: People with substance use disorders generally have unhealthy diets, including limited intake of fruit and vegetables. Evidence shows substantial health benefits from increasing fruit and vegetable consumption on various indicators and possibly also psychological distress. A pilot study has indicated that supplementation with fruit smoothie could be promising also among people receiving opioid agonist therapy for opioid dependence. FruktBAR will compare the efficacy of added fruit smoothie supplementation to people receiving opioid agonist therapy compared to standard treatment without added supplementation.

Methods: FruktBAR is a multicentre, randomised controlled trial. The trial will aim to recruit 302 patients receiving opioid agonist therapy. The intervention involves daily supplementation with 250 ml fruit smoothie including a variety of fruits such as apple, pineapple, mango, bananas, orange, blueberries, passion fruit, coconut, lime, and blackcurrant. The main endpoints are 16 weeks after intervention initiation. Participants will be included and followed up during and after the intervention. The target group will be patients with opioid dependence receiving opioid agonist therapy from involved outpatient clinics in Bergen and Stavanger, two of the largest cities in Norway. The main outcome is psychological distress assessed with Hopkins Symptom Checklist (SCL-10) at the end of the intervention period 16 weeks after initiation, and will be compared between the intervention and control arms. Secondary outcome measures are changes in fatigue, physical functioning assessed with a 4-minute step-test, health-related quality of life, biochemical indicators of inflammation, and biochemical indicators of fruit intake.

Discussion: This study will inform on the relative advantages or disadvantages of fruit supplementation in addition to the current medically and psychologically oriented treatment of people receiving opioid agonist therapy. If the supplementation is efficacious, it can be considered for further scale-up.

Trial registration: Registered 2022-02-08 in ClinicalTrials.gov , identifier NCT05229770.

Keywords: Food supplementations; Fruit; Opiate substitution treatment; Substance-related disorders.

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Conflict of interest statement

The authors have no competing interests.

Figures

Fig. 1
Fig. 1
The figure gives an overview of the timing of the intervention and follow-up for the study. * The arrows are indications of when the various measurements are timed
See this image and copyright information in PMC

References

    1. GBD 2013 Mortality and Causes of Death Collaborators Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2015;385(9963):117–171. doi: 10.1016/S0140-6736(14)61682-2. - DOI - PMC - PubMed
    1. Hjellum K, Wåde-Engelsen M: BrukerPlan 2015: En kartlegging av kommunale tjenestemottakere over 18 år med psykiske problem, rusrelaterte problem, eller samtidige rus- og psykiske problem (ROP). In.: Bergen kommune; 2016.
    1. Saeland M, Haugen M, Eriksen FL, Wandel M, Smehaugen A, Bohmer T, Oshaug A. High sugar consumption and poor nutrient intake among drug addicts in Oslo, Norway. Br J Nutr. 2011;105(4):618–624. doi: 10.1017/S0007114510003971. - DOI - PubMed
    1. Saeland M, Wandel M, Bohmer T, Haugen M. Abscess infections and malnutrition--a cross-sectional study of polydrug addicts in Oslo, Norway. Scand J Clin Lab Invest. 2014;74(4):322–328. doi: 10.3109/00365513.2014.891256. - DOI - PubMed
    1. Aune D, Keum N, Giovannucci E, Fadnes LT, Boffetta P, Greenwood DC, Tonstad S, Vatten LJ, Riboli E, Norat T. Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies. Am J Clin Nutr. 2018;108(5):1069–1091. doi: 10.1093/ajcn/nqy097. - DOI - PMC - PubMed

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