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. 2022 Oct:128:36-38.
doi: 10.1016/j.placenta.2022.08.013. Epub 2022 Aug 29.

Endothelial nitric oxide deficiency results in abnormal placental metabolism

Hannah George  1 , Katherine L Steeves  1 , Grace V Mercer  1 , Zahra Aghaei  1 , Céline M Schneider  1 , Lindsay S Cahill  2
Affiliations

Endothelial nitric oxide deficiency results in abnormal placental metabolism

Hannah George et al. Placenta. 2022 Oct.

Abstract

Placental metabolism determines the amount of nutrients available to the fetus and may be altered in pregnancies complicated by fetal growth restriction (FGR). To study which metabolites are associated with FGR, we performed 1H high-resolution magic angle spinning magnetic resonance spectroscopy of placental tissue from endothelial nitric oxide synthase knockout (eNOS KO) mice, a model of FGR, and C57BL/6J controls at embryonic day 17.5 (n = 24/genotype). The relative concentration of glucose was increased in the placentas of eNOS KO mice compared to controls (p = 0.006). This study highlights the potential for glucose as a biomarker of abnormal placental metabolism that leads to FGR.

Keywords: Endothelial nitric oxide synthase; Fetal growth restriction; Glucose; Metabolomics; Mouse; Placenta.

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Conflict of interest statement

Declaration of competing interest No conflicts of interest are declared by the authors.

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