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. 2022 Oct;22(10):1421-1422.
doi: 10.1016/S1473-3099(22)00524-2. Epub 2022 Sep 1.

Evasion of neutralising antibodies by omicron sublineage BA.2.75

Daniel J Sheward  1 , Changil Kim  2 , Julian Fischbach  2 , Sandra Muschiol  2 , Roy A Ehling  3 , Niklas K Björkström  4 , Gunilla B Karlsson Hedestam  2 , Sai T Reddy  3 , Jan Albert  2 , Thomas P Peacock  5 , Ben Murrell  6
Affiliations

Evasion of neutralising antibodies by omicron sublineage BA.2.75

Daniel J Sheward et al. Lancet Infect Dis. 2022 Oct.
No abstract available

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Conflict of interest statement

STR is a cofounder of, and held shares in, deepCDR Biologics, which has been acquired by Alloy Therapeutics. DJS, GBKH, and BM have intellectual property rights associated with antibodies that neutralise omicron variants. All other authors declare no competing interests.

Figures

Figure
Figure
Evasion of neutralising antibodies by BA.2.75 (A) Neutralising 50% inhibitory concentration (IC50) titres (ng/μl) for monoclonal antibodies against ancestral B.1 (D614G) and omicron sublineages BA.2, BA.5, and BA.2.75 in a pseudovirus neutralisation assay. (B) Neutralisation of BA.2.75 relative to BA.2, BA.5, and B.1 by serum (n=20) from blood donated Nov 8–14, 2021, in Stockholm, Sweden, before a wave of infections dominated by BA.1 and BA.2 (left-hand chart). Neutralisation by serum (n=20) donated April 11–17, 2022, after the infection wave (right-hand chart). Values shown above the charts in (B) are the geometric mean ID50 titres. Serum with an ID50 less than the lowest dilution tested (20, dotted line) is plotted as 20. ID50=50% inhibitory dilution.
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References

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