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Review
. 2023 Feb;31(2):159-172.
doi: 10.1016/j.tim.2022.08.010. Epub 2022 Sep 1.

Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer

Ni Wang  1 , Jing-Yuan Fang  2
Affiliations
Review

Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer

Ni Wang et al. Trends Microbiol. 2023 Feb.

Abstract

Colorectal cancer (CRC), one of the most prevalent cancers, has complex etiology. The dysbiosis of intestinal bacteria has been highlighted as an important contributor to CRC. Fusobacterium nucleatum, an oral anaerobic opportunistic pathogen, is enriched in both stools and tumor tissues of patients with CRC. Therefore, F. nucleatum is considered to be a risk factor for CRC. This review summarizes the biological characteristics and the mechanisms underlying the regulatory behavior of F. nucleatum in the tumorigenesis and progression of CRC. F. nucleatum as a marker for the early warning and prognostic prediction of CRC, and as a target for prevention and treatment, is also described.

Keywords: Fusobacterium nucleatum; biomarker; colorectal cancer; immune microenvironment; proliferation.

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Conflict of interest statement

Declaration of interests The authors declare no competing interest.

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