Update of the diagnostic and therapeutic guidelines for gastro-entero-pancreatic neuroendocrine neoplasms (recommended by the Polish Network of Neuroendocrine Tumours) [Aktualizacja zaleceń ogólnych dotyczących postępowania diagnostyczno-terapeutycznego w nowotworach neuroendokrynnych układu pokarmowego (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)]

Beata Kos-Kudła¹, Wanda Foltyn², Anna Malczewska¹, Tomasz Bednarczuk³, Marek Bolanowski⁴, Małgorzata Borowska⁵, Ewa Chmielik⁶, Jarosław B Ćwikła⁷, Iwona Gisterek⁸, Daria Handkiewicz-Junak⁹, Alicja Hubalewska-Dydejczyk¹⁰, Barbara Jarząb⁹, Michał Jarząb¹¹, Roman Junik¹², Dariusz Kajdaniuk¹³, Grzegorz Kamiński¹⁴, Agnieszka Kolasińska-Ćwikła¹⁵, Aldona Kowalska¹⁶, Leszek Królicki¹⁷, Maciej Krzakowski¹⁸, Jolanta Kunikowska¹⁷, Katarzyna Kuśnierz¹⁹, Andrzej Lewiński²⁰, Łukasz Liszka²¹, Magdalena Londzin-Olesik¹, Bogdan Marek¹³, Anna Nasierowska-Guttmejer²², Ewa Nowakowska-Duława²³, Marianne E Pavel²⁴, Joanna Pilch-Kowalczyk²⁵, Jarosław Reguła²⁶, Violetta Rosiek¹, Marek Ruchała²⁷, Grażyna Rydzewska²⁸, Lucyna Siemińska¹³, Anna Sowa-Staszczak¹⁰, Teresa Starzyńska²⁹, Zoran Stojčev³⁰, Janusz Strzelczyk¹, Michał Studniarek³¹, Anhelli Syrenicz³², Marek Szczepkowski³³, Ewa Wachuła³⁴, Wojciech Zajęcki⁵, Anna Zemczak¹, Wojciech Zgliczyński³⁵, Krzysztof Zieniewicz³⁶

Affiliations

¹ Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.
² Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland. wandafoltyn@poczta.onet.pl.
³ Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
⁴ Chair and Department of Endocrinology, Diabetes, and Isotope Therapy, Medical University of Wroclaw, Wroclaw, Poland.
⁵ Department of Endocrinology and Neuroendocrine Tumours, Medical University of Silesia, Katowice, Poland.
⁶ Tumor Pathology Department, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.
⁷ Department of Cardiology and Internal Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
⁸ Chair of Oncology and Radiotherapy, Medical University of Silesia, Katowice, Poland.
⁹ Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Brench, Gliwice, Poland.
¹⁰ Chair and Department of Endocrinology, Jagiellonian University Medical College, Cracow, Poland.
¹¹ Breast Unit, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.
¹² Department of Endocrinology and Diabetology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.
¹³ Division of Pathophysiology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.
¹⁴ Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine, Warsaw, Poland.
¹⁵ Department of Oncology and Radiotherapy, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Warsaw, Poland.
¹⁶ Department of Endocrinology, Holycross Cancer Centre, Collegium Medicum, Jan Kochanowski University, Kielce, Poland.
¹⁷ Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland.
¹⁸ Department of Lung Cancer and Thoracic Tumours, Maria Sklodowska-Curie Memorial, National Research Institute of Oncology, Warsaw, Poland.
¹⁹ Department of Gastrointestinal Surgery, Medical University of Silesia, Katowice, Poland.
²⁰ Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland.
²¹ Department of Pathomorphology and Molecular Diagnostics, Medical University of Silesia, Katowice, Poland.
²² Faculty of Medicine, Lazarski University in Warsaw, Warsaw, Poland.
²³ Department of Gastroenterology and Hepatology, Medical University of Silesia, Katowice, Poland.
²⁴ Department of Medicine 1, Endocrinology and Diabetology, Friedrich Alexander University of Erlangen-Nürnberg, Erlangen, Germany.
²⁵ Department of Radiology and Nuclear Medicine, Medical University of Silesia, Katowice, Poland.
²⁶ Department of Oncological Gastroenterology, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Warsaw, Poland.
²⁷ Department of Endocrinology, Metabolism and Internal Diseases, Medical University in Poznan, Poznan, Poland.
²⁸ Department of Internal Medicine and Gastroenterology, Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland.
²⁹ Department of Gastroenterology, Medical Pomeranian University in Szczecin, Szczecin, Poland.
³⁰ Department of Oncology and Breast Diseases, Centre of Postgraduate Medical Education, Warsaw, Poland.
³¹ Department of Radiology, Medical University of Gdansk, Gdansk, Poland.
³² Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University, Szczecin, Poland.
³³ Clinical Department of Colorectal, General and Oncological Surgery, Centre of Postgraduate Medical Education, Warsaw, Poland.
³⁴ Department of Clinical Oncology, Gdynia Oncology Centre of the Polish Red Cross Maritime Hospital, Gdynia, Poland.
³⁵ Department of Endocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland.
³⁶ Chair and Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.

PMID: 36059171
DOI: 10.5603/EP.a2022.0049

Free article

Update of the diagnostic and therapeutic guidelines for gastro-entero-pancreatic neuroendocrine neoplasms (recommended by the Polish Network of Neuroendocrine Tumours) [Aktualizacja zaleceń ogólnych dotyczących postępowania diagnostyczno-terapeutycznego w nowotworach neuroendokrynnych układu pokarmowego (rekomendowane przez Polską Sieć Guzów Neuroendokrynnych)]

Beata Kos-Kudła et al. Endokrynol Pol. 2022.

Free article

. 2022;73(3):387-454.

doi: 10.5603/EP.a2022.0049.

Authors

Affiliations

¹ Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.
² Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland. wandafoltyn@poczta.onet.pl.
³ Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
⁴ Chair and Department of Endocrinology, Diabetes, and Isotope Therapy, Medical University of Wroclaw, Wroclaw, Poland.
⁵ Department of Endocrinology and Neuroendocrine Tumours, Medical University of Silesia, Katowice, Poland.
⁶ Tumor Pathology Department, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.
⁷ Department of Cardiology and Internal Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
⁸ Chair of Oncology and Radiotherapy, Medical University of Silesia, Katowice, Poland.
⁹ Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Brench, Gliwice, Poland.
¹⁰ Chair and Department of Endocrinology, Jagiellonian University Medical College, Cracow, Poland.
¹¹ Breast Unit, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.
¹² Department of Endocrinology and Diabetology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.
¹³ Division of Pathophysiology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.
¹⁴ Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine, Warsaw, Poland.
¹⁵ Department of Oncology and Radiotherapy, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Warsaw, Poland.
¹⁶ Department of Endocrinology, Holycross Cancer Centre, Collegium Medicum, Jan Kochanowski University, Kielce, Poland.
¹⁷ Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland.
¹⁸ Department of Lung Cancer and Thoracic Tumours, Maria Sklodowska-Curie Memorial, National Research Institute of Oncology, Warsaw, Poland.
¹⁹ Department of Gastrointestinal Surgery, Medical University of Silesia, Katowice, Poland.
²⁰ Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland.
²¹ Department of Pathomorphology and Molecular Diagnostics, Medical University of Silesia, Katowice, Poland.
²² Faculty of Medicine, Lazarski University in Warsaw, Warsaw, Poland.
²³ Department of Gastroenterology and Hepatology, Medical University of Silesia, Katowice, Poland.
²⁴ Department of Medicine 1, Endocrinology and Diabetology, Friedrich Alexander University of Erlangen-Nürnberg, Erlangen, Germany.
²⁵ Department of Radiology and Nuclear Medicine, Medical University of Silesia, Katowice, Poland.
²⁶ Department of Oncological Gastroenterology, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Warsaw, Poland.
²⁷ Department of Endocrinology, Metabolism and Internal Diseases, Medical University in Poznan, Poznan, Poland.
²⁸ Department of Internal Medicine and Gastroenterology, Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland.
²⁹ Department of Gastroenterology, Medical Pomeranian University in Szczecin, Szczecin, Poland.
³⁰ Department of Oncology and Breast Diseases, Centre of Postgraduate Medical Education, Warsaw, Poland.
³¹ Department of Radiology, Medical University of Gdansk, Gdansk, Poland.
³² Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University, Szczecin, Poland.
³³ Clinical Department of Colorectal, General and Oncological Surgery, Centre of Postgraduate Medical Education, Warsaw, Poland.
³⁴ Department of Clinical Oncology, Gdynia Oncology Centre of the Polish Red Cross Maritime Hospital, Gdynia, Poland.
³⁵ Department of Endocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland.
³⁶ Chair and Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.

PMID: 36059171
DOI: 10.5603/EP.a2022.0049

Abstract

Continuous progress in the diagnostics and treatment of neuroendocrine neoplasms (NENs), the emerging results of new clinical trials, and the new guidelines issued by medical societies have prompted experts from the Polish Network of Neuroendocrine Tumours to update the 2017 recommendations regarding the management of neuroendocrine neoplasms. This article presents the general recommendations for the management of NENs, resulting from the findings of the experts participating in the Fourth Round Table Conference, entitled "Polish Guidelines for the Diagnostics and Treatment of Neuroendocrine Neoplasms of the gastrointestinal tract, Żelechów, June 2021". Drawing from the extensive experience of centres treating these cancers, we hope that we have managed to formulate the optimal method of treating patients with NENs, applying the latest reports and achievements in the field of medicine, which can be effectively implemented in our country. The respective parts of this work present the approach to the management of: NENs of the stomach and duodenum (including gastrinoma), pancreas, small intestine, and appendix, as well as large intestine.

Keywords: diagnostics; gastro-entero-pancreatic neuroendocrine neoplasms; treatment.

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