Pancreatic neuroendocrine neoplasms - update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne trzustki - uaktualnione zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynych)]

Beata Kos-Kudła¹, Violetta Rosiek¹, Małgorzata Borowska², Tomasz Bednarczuk³, Marek Bolanowski⁴, Ewa Chmielik⁵, Jarosław B Ćwikła⁶, Wanda Foltyn⁷, Iwona Gisterek⁸, Daria Handkiewicz-Junak⁹, Alicja Hubalewska-Dydejczyk¹⁰, Michał Jarząb¹¹, Roman Junik¹², Dariusz Kajdaniuk¹³, Grzegorz Kamiński¹⁴, Agnieszka Kolasińska-Ćwikła¹⁵, Aldona Kowalska¹⁶, Leszek Królicki¹⁷, Jolanta Kunikowska¹⁷, Katarzyna Kuśnierz¹⁸, Andrzej Lewiński¹⁹, Łukasz Liszka²⁰, Magdalena Londzin-Olesik¹, Bogdan Marek¹³, Anna Malczewska¹, Anna Nasierowska-Guttmejer²¹, Ewa Nowakowska-Duława²², Marianne E Pavel²³, Joanna Pilch-Kowalczyk²⁴, Jarosław Reguła²⁵, Marek Ruchała²⁶, Grażyna Rydzewska²⁷, Lucyna Siemińska¹³, Anna Sowa-Staszczak¹⁰, Teresa Starzyńska²⁸, Zoran Stojčev²⁹, Janusz Strzelczyk¹, Michał Studniarek³⁰, Anhelli Syrenicz³¹, Marek Szczepkowski³², Ewa Wachuła³³, Wojciech Zajęcki², Anna Zemczak¹, Wojciech Zgliczyński³⁴, Krzysztof Zieniewicz³⁵

Affiliations

¹ Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.
² Department of Endocrinology and Neuroendocrine Tumours, Medical University of Silesia, Katowice, Poland.
³ Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
⁴ Chair and Department of Endocrinology, Diabetes, and Isotope Therapy, Medical University of Wroclaw, Wroclaw, Poland.
⁵ Tumor Pathology Department, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.
⁶ Department of Cardiology and Internal Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
⁷ Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland. wandafoltyn@poczta.onet.pl.
⁸ Chair of Oncology and Radiotherapy, Medical University of Silesia, Katowice, Poland.
⁹ Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Brench, Gliwice, Poland.
¹⁰ Chair and Department of Endocrinology, Jagiellonian University Medical College, Cracow, Poland.
¹¹ Breast Unit, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.
¹² Department of Endocrinology and Diabetology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.
¹³ Division of Pathophysiology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.
¹⁴ Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine, Warsaw, Poland.
¹⁵ Department of Oncology and Radiotherapy, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Warsaw, Poland.
¹⁶ Department of Endocrinology, Holycross Cancer Centre, Collegium Medicum, Jan Kochanowski University, Kielce, Poland.
¹⁷ Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland.
¹⁸ Department of Gastrointestinal Surgery, Medical University of Silesia, Katowice, Poland.
¹⁹ Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland.
²⁰ Department of Pathomorphology and Molecular Diagnostics, Medical University of Silesia, Katowice, Poland.
²¹ Faculty of Medicine, Lazarski University in Warsaw, Warsaw, Poland.
²² Department of Gastroenterology and Hepatology, Medical University of Silesia, Katowice, Poland.
²³ Department of Medicine 1, Endocrinology and Diabetology, Friedrich Alexander University of Erlangen-Nürnberg, Erlangen, Germany.
²⁴ Department of Radiology and Nuclear Medicine, Medical University of Silesia, Katowice, Poland.
²⁵ Department of Oncological Gastroenterology, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Warsaw, Poland.
²⁶ Department of Endocrinology, Metabolism and Internal Diseases, Medical University in Poznan, Poznan, Poland.
²⁷ Department of Internal Medicine and Gastroenterology, Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland.
²⁸ Department of Gastroenterology, Medical Pomeranian University in Szczecin, Szczecin, Poland.
²⁹ Department of Oncology and Breast Diseases, Centre of Postgraduate Medical Education, Warsaw, Poland.
³⁰ Department of Radiology, Medical University of Gdansk, Gdansk, Poland.
³¹ Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University, Szczecin, Poland.
³² Clinical Department of Colorectal, General and Oncological Surgery, Centre of Postgraduate Medical Education, Warsaw, Poland.
³³ Department of Clinical Oncology, Gdynia Oncology Centre of the Polish Red Cross Maritime Hospital, Gdynia, Poland.
³⁴ Department of Endocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland.
³⁵ Chair and Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.

PMID: 36059173
DOI: 10.5603/EP.a2022.0050

Free article

Pancreatic neuroendocrine neoplasms - update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne trzustki - uaktualnione zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynych)]

Beata Kos-Kudła et al. Endokrynol Pol. 2022.

Free article

. 2022;73(3):491-548.

doi: 10.5603/EP.a2022.0050.

Authors

Affiliations

¹ Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.
² Department of Endocrinology and Neuroendocrine Tumours, Medical University of Silesia, Katowice, Poland.
³ Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
⁴ Chair and Department of Endocrinology, Diabetes, and Isotope Therapy, Medical University of Wroclaw, Wroclaw, Poland.
⁵ Tumor Pathology Department, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.
⁶ Department of Cardiology and Internal Medicine, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
⁷ Department of Endocrinology and Neuroendocrine Tumours, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland. wandafoltyn@poczta.onet.pl.
⁸ Chair of Oncology and Radiotherapy, Medical University of Silesia, Katowice, Poland.
⁹ Department of Nuclear Medicine and Endocrine Oncology, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Brench, Gliwice, Poland.
¹⁰ Chair and Department of Endocrinology, Jagiellonian University Medical College, Cracow, Poland.
¹¹ Breast Unit, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.
¹² Department of Endocrinology and Diabetology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.
¹³ Division of Pathophysiology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland.
¹⁴ Department of Endocrinology and Radioisotope Therapy, Military Institute of Medicine, Warsaw, Poland.
¹⁵ Department of Oncology and Radiotherapy, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Warsaw, Poland.
¹⁶ Department of Endocrinology, Holycross Cancer Centre, Collegium Medicum, Jan Kochanowski University, Kielce, Poland.
¹⁷ Nuclear Medicine Department, Medical University of Warsaw, Warsaw, Poland.
¹⁸ Department of Gastrointestinal Surgery, Medical University of Silesia, Katowice, Poland.
¹⁹ Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland.
²⁰ Department of Pathomorphology and Molecular Diagnostics, Medical University of Silesia, Katowice, Poland.
²¹ Faculty of Medicine, Lazarski University in Warsaw, Warsaw, Poland.
²² Department of Gastroenterology and Hepatology, Medical University of Silesia, Katowice, Poland.
²³ Department of Medicine 1, Endocrinology and Diabetology, Friedrich Alexander University of Erlangen-Nürnberg, Erlangen, Germany.
²⁴ Department of Radiology and Nuclear Medicine, Medical University of Silesia, Katowice, Poland.
²⁵ Department of Oncological Gastroenterology, Maria Sklodowska-Curie Memorial National Research Institute of Oncology, Warsaw, Poland.
²⁶ Department of Endocrinology, Metabolism and Internal Diseases, Medical University in Poznan, Poznan, Poland.
²⁷ Department of Internal Medicine and Gastroenterology, Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland.
²⁸ Department of Gastroenterology, Medical Pomeranian University in Szczecin, Szczecin, Poland.
²⁹ Department of Oncology and Breast Diseases, Centre of Postgraduate Medical Education, Warsaw, Poland.
³⁰ Department of Radiology, Medical University of Gdansk, Gdansk, Poland.
³¹ Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University, Szczecin, Poland.
³² Clinical Department of Colorectal, General and Oncological Surgery, Centre of Postgraduate Medical Education, Warsaw, Poland.
³³ Department of Clinical Oncology, Gdynia Oncology Centre of the Polish Red Cross Maritime Hospital, Gdynia, Poland.
³⁴ Department of Endocrinology, Centre of Postgraduate Medical Education, Warsaw, Poland.
³⁵ Chair and Department of General, Transplant, and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.

PMID: 36059173
DOI: 10.5603/EP.a2022.0050

Abstract

In this paper, we present the current guidelines for the diagnostics and management of pancreatic neuroendocrine neoplasms (PanNENs) developed by Polish experts providing care for these patients in everyday clinical practice. In oncological diagnostics, in addition to biochemical tests, molecular identification with the use of NETest liquid biopsy and circulating microRNAs is gaining importance. Both anatomical and functional examinations (including new radiopharmaceuticals) are used in imaging diagnostics. Histopathological diagnosis along with immunohistochemical examination still constitute the basis for therapeutic decisions. Whenever possible, surgical procedure is the treatment of choice. Pharmacological management including biotherapy, radioisotope therapy, targeted molecular therapy and chemotherapy are important methods of systemic therapy. Treatment of PanNENs requires a multidisciplinary team of specialists in the field of neuroendocrine neoplasms.

Keywords: diagnostics; functional; non-functional; pancreatic neuroendocrine neoplasms; recommendations; therapy.

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Pancreatic neuroendocrine neoplasms - update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne trzustki - uaktualnione zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynych)]

Affiliations

Pancreatic neuroendocrine neoplasms - update of the diagnostic and therapeutic guidelines (recommended by the Polish Network of Neuroendocrine Tumours) [Nowotwory neuroendokrynne trzustki - uaktualnione zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynych)]

Authors

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Abstract

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