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Review
. 2022 Aug 27:15:1819-1840.
doi: 10.2147/JMDH.S359282. eCollection 2022.

Review on Nanomaterials and Nano-Scaled Systems for Topical and Systemic Delivery of Antifungal Drugs

Gamachu Diba Nagasa #  1 , Anteneh Belete #  2
Affiliations
Review

Review on Nanomaterials and Nano-Scaled Systems for Topical and Systemic Delivery of Antifungal Drugs

Gamachu Diba Nagasa et al. J Multidiscip Healthc. .

Abstract

Fungal infections are human infections that topically affect the skin, mucous membranes, or more serious, invasive, and systemic diseases of the internal organs. The design and advancement of the formulation and approach of administration for therapeutic agents depend on many variables. The correlation between the formulations, mode of administration, pharmacokinetics, toxicity and clinical indication must be thoroughly studied for the successful evolution of suitable drug delivery systems. There are several NP formulations that serve as good delivery approaches for antifungal drugs. This paper covers various groups of nanoparticles utilized in antifungal drug delivery, such as phospholipid-based vesicles (nanovesicles), non-phospholipid vesicles, polymeric nanoparticles, inorganic nanoparticles and dendrimers, whereby their advantages and drawbacks are emphasized. Many in vitro or cell culture studies with NP formulations achieve an adequate high drug-loading capacity; they do not reach the clinically significant concentrations anticipated for in vivo studies. Because of this, the transfer of these nano-formulations from the laboratory to the clinic could be aided by focusing studies on overcoming problems related to nanoparticle stability, drug loading, and high production and standardization costs.

Keywords: anti-fungal drugs; inorganic nanoparticles; nano-scaled; nano-vesicles; polymeric nanoparticles.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Virulence attributes of a prototypic human pathogenic fungus in interaction with the host.
Figure 2
Figure 2
Iron homeostasis in Saccharomyces cerevisiae and major human pathogenic fungi.
Figure 3
Figure 3
Schematic representation of the most commonly used nanomedicine types composed of different kinds of materials.
See this image and copyright information in PMC

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