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Case Reports
. 2022 Aug 24:39:101727.
doi: 10.1016/j.rmcr.2022.101727. eCollection 2022.

Pulmonary calcinosis associated with Alport syndrome

Valentine Mismetti  1 , Marie-Pierre Perquis  1 , Lina Hamdi  1 , Marios E Froudarakis  1 , Jean-Michel Vergnon  1
Affiliations
Case Reports

Pulmonary calcinosis associated with Alport syndrome

Valentine Mismetti et al. Respir Med Case Rep. .

Abstract

We report the case of a 48-year-old woman under dialysis from chronic renal failure (CRF) since the age of 27, due to Alport syndrome. The patient underwent routine chest X-ray on which diffuse micronodules were shown. Chest computed tomography showed partially calcified micronodules with centrilobular distribution respecting the subpleural spaces and predominant in the upper lobar regions. Metastatic pulmonary calcinosis was confirmed by the bone scan with an overall course of 29 years. This is the first reported case of pulmonary calcinosis from CRF due to Alport syndrome.

Keywords: Alport syndrome; Bone scan; Pulmonary calcinosis; Renal failure.

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Conflict of interest statement

The authors have no conflicts of interest to declare in relation to this manuscript.

Figures

Fig. 1
Fig. 1
Patient's imaging: A/chest X-ray with diffuse bilateral opacities, predominant in the upper lobes, B and C/chest computed tomography (CCT) with diffuse centrilobular micronodules, respecting subpleural, fissural and peribronchovascular spaces (parenchymal and bone windows respectively), D/CCT (mediastinal window) showing calcified tracheobronchial tree E/bone scan with bilateral lung fixation.
See this image and copyright information in PMC

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