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Comparative Study
. 1987 Apr;31(4):635-7.
doi: 10.1128/AAC.31.4.635.

Alteration of gentamicin and cefazolin kinetics with control of the hypothyroid state in humans

P Chanson, V Joly, A Contrepois, J J Garaud, J Bauchet, J Mohler, P C Nguyen, C Carbon
Comparative Study

Alteration of gentamicin and cefazolin kinetics with control of the hypothyroid state in humans

P Chanson et al. Antimicrob Agents Chemother. 1987 Apr.

Abstract

We studied the effect of the control of the hypothyroid state in humans on the pharmacokinetic parameters of cefazolin and gentamicin after a single intravenous injection. These two antibiotics were chosen because of their different patterns of binding to serum albumin (0% for gentamicin and 82% for cefazolin). In hypothyroidism, the behavior of cefazolin only was altered, with a decrease in the total body clearance, possibly due to reduced urinary excretion, and a decrease in the volume of distribution without a significant alteration of cefazolin binding to serum protein.

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