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Case Reports
. 2022 Aug 31;9(8):e00845.
doi: 10.14309/crj.0000000000000845. eCollection 2022 Aug.

Liver Failure in Neonates With G6PD Deficiency

Milaan Shah  1 , Vani Gopalareddy  2
Affiliations
Case Reports

Liver Failure in Neonates With G6PD Deficiency

Milaan Shah et al. ACG Case Rep J. .

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a commonly inherited enzyme defect that can present with hemolysis, hyperbilirubinemia, and jaundice and may cause kidney and liver dysfunction. G6PD deficiency may serve as a cofactor for chronic liver disease; however, an association with liver failure is not well described. We present the cases of 2 neonates with G6PD deficiency and progressive liver failure resistant to treatment with ursodiol that eventually required liver transplantation. Our cases underscore the importance of monitoring liver function in jaundiced neonates with underlying G6PD deficiency and demonstrate the potential precipitation of liver disease by G6PD deficiency.

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Figures

Figure 1.
Figure 1.
(A) Low-power view of the liver core biopsy showing multiple giant cells present. (B) High-power view of the liver core biopsy showing multiple giant cells with cholestasis, apoptosis, and a background of mixed inflammation with lymphocytes and eosinophils. (C) A trichrome stain of the tissue demonstrating extenuation of the sinusoidal fibrosis.
See this image and copyright information in PMC

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