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. 2022;5(4):139-148.
Epub 2022 Jan 31.

Non-Pharmacological Interventions for the Hallucinations in Patients with Dementia. A Cross-Over Randomized Controlled Trial

Dimitriou Tatiana-Danai  1 , Papatriantafyllou John  2 , Konsta Anastasia  3 , Kazis Dimitrios  1 , Athanasiadis Loukas  3 , Ioannidis Panagiotis  1 , Koutsouraki Efrosini  1 , Tegos Thomas  1 , Tsolaki Magda  1
Affiliations

Non-Pharmacological Interventions for the Hallucinations in Patients with Dementia. A Cross-Over Randomized Controlled Trial

Dimitriou Tatiana-Danai et al. J Clin Cases Rep. 2022.

Abstract

Objective: Hallucinations is a core characteristic symptom in Lewy Body Dementia (DLB) and Parkinson's Dementia (PDD). It may also appear at the late stages of Alzheimer's disease (AD). They are not easily managed, and they are associated with cognitive decline, earlier institutionalization, increased mortality, and increased caregivers' burden.

Design/setting: This is a cross-over RCT. The participants were randomly assigned in 6 different groups of 10 patients each.

Participants: 60 dementia patients (different types and stages of dementia).

Interventions: The three non-pharmacological interventions used are: A) Validation therapy (VT) in a Psycho-educational program, B) Reminiscence therapy (RT) and C) Music therapy (MT). Each intervention lasted for 5 days and there was an interval of two days, as a wash-out period (all the interventions had a duration of 3 weeks).

Measurements: The measurements which were used at baseline were: MMSE, ACE-R, GDS, FRSDD and NPI questionnaire at baseline and after each intervention.

Results: The most effective combination for the reduction of the hallucinations is: VT/Psycho-educational program (p = 0.005), MT (p = 0.007) and RT (p = 0.022). The same combination applies for the caregivers' distress: VT/Psychoeducational program (p = 0.010) - MT (p = 0.023) - RT (p = 0.036).

Conclusion: VT/Psycho-educational program followed by MT, followed by RT is an effective combination of non-pharmacological interventions that can reduce hallucinations in patients with dementia and caregivers' burden. Non-pharmacological interventions should be further examined as an effective alternative for the reduction of the hallucinations in dementia.

Keywords: BPSD; Crossover randomized trial; Dementia; Hallucinations; Non-pharmacological.

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References

    1. Lin W, Xie YC, Cheng PY et al. (2018) Association of visual hallucinations with very mild degenerative dementia due to dementia with Lewy bodies. Plos One 13(10): e0205909. - PMC - PubMed
    1. Ukai K (2019) Tactile hallucinations in dementia with lewy bodies. Psychogeriatrics 19(5): 435–439. - PubMed
    1. Tsunoda N, Hashimoto M, Ishikawa T et al. (2018) Clinical features of auditory hallucinations in patients with dementia with lewy bodies: A soundtrack of visual hallucinations. The Journal of Clinical Psychiatry 79(3): 17m11623. - PubMed
    1. Swann P and O’Brien JT (2019) Management of visual hallucinations in dementia and parkinson’s disease. International Psychogeriatrics 31(6): 815–836. - PubMed
    1. Tartaglia MC, Kertesz A, Ang LC (2008) Delusions and hallucinations in frontotemporal dementia: A clinicopathologic case report. Cognitive and Behavioral Neurology 21(2): 107–110. - PubMed

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