Sex-specific Cutoff Values of Visceral Fat Area for Lean vs. Overweight/Obese Nonalcoholic Fatty Liver Disease in Asians

Abstract

Background and aims: Visceral obesity is a risk factor for nonalcoholic fatty liver disease (NAFLD). We investigated sex-specific optimal cutoff values for visceral fat area (VFA) associated with lean and overweight/obese NAFLD in an Asian population.

Methods: This retrospective study included 678 potential living liver donors (mean age, 30.8±9.4 years; 434 men and 244 women) who had undergone abdominal computed tomography (CT) imaging and liver biopsy between November 2016 and October 2017. VFA was measured using single-slice abdominal CT. NAFLD was evaluated by liver biopsy (≥5% hepatic steatosis). Receiver operating characteristic curve analysis was used to determine cutoff values for VFA associated with lean (body mass index [BMI] <23 kg/m²) and overweight/obese (BMI ≥23 kg/m²) NAFLD.

Results: Area under the curve (AUC) values with 95% confidence intervals (CI) for VFA were 0.82 (95% CI, 0.75-0.88) for lean and 0.74 (95% CI, 0.69-0.79) for overweight/obese men with NAFLD. The AUC values were 0.67 (95% CI, 0.58-0.75) for lean and 0.71 (95% CI, 0.62-0.80) for overweight/obese women with NAFLD. The cutoff values for VFA associated with lean NAFLD were 50.2 cm² in men and 40.5 cm² in women. The optimal cutoff values for VFA associated with overweight/obese NAFLD were 100.6 cm² in men and 68.0 cm² in women.

Conclusions: Sex-specific cutoff values for VFA may be useful for identifying subjects at risk of lean and overweight/obese NAFLD.

Keywords: Adipose tissue; Computed tomography.; Hepatic steatosis; Liver biopsy.

Fig. 1. Receiver operating characteristic curves for visceral fat area to identify (A) lean nonalcoholic fatty liver disease (NAFLD) in men, (B) in lean women, (C) in overweight/obese men, and (D) overweight/obese in women.