Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct;26(10):767-774.
doi: 10.1007/s11916-022-01079-x. Epub 2022 Sep 5.

The Role of the Autonomic Nervous System in Headache: Biomarkers and Treatment

Affiliations
Review

The Role of the Autonomic Nervous System in Headache: Biomarkers and Treatment

Richard Gevirtz. Curr Pain Headache Rep. 2022 Oct.

Abstract

Purpose of review: In this review, the role of the autonomic nervous system in tension-type headache and migraine is reviewed.

Recent findings: A pathophysiological model for tension-type headache is proposed that is compatible with most physiological and behavioral literature. A treatment protocol is described that follows from this model. For migraine, incorporating autonomic factors into the pathophysiology offers rationales for behavioral interventions that have been shown to be useful in migraine treatment and a biofeedback protocol is proposed.

Keywords: Autonomic nervous system; Biofeedback; Headache.

PubMed Disclaimer

Conflict of interest statement

The author does not have existing conflicts of interest.

Figures

Fig. 1
Fig. 1
A proposed model for the pathophysiology of tension-type headache

Similar articles

Cited by

References

    1. Bentivegna E, Luciani M, Paragliola V, Baldari F, Lamberti PA, Conforti G, Martelletti P. Recent advancements in tension-type headache: a narrative review. Expert Rev Neurother. 2021 doi: 10.1080/14737175.2021.1943363. - DOI - PubMed
    1. Karikari TK, Charway-Felli A, Höglund K, Blennow K, Zetterberg H. Commentary: global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Front Neurol. 2018 doi: 10.3389/fneur.2018.00201. - DOI - PMC - PubMed
    1. Stovner LJ, Nichols E, Steiner TJ, Abd-Allah F, Abdelalim A, Al-Raddadi RM, Murray CJ. Global, regional, and national burden of migraine and tension-type headache, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2018;17(11):954–976. doi: 10.1016/S1474-4422(18)30322-3. - DOI - PMC - PubMed
    1. Steel SJ, Robertson CE, Whealy MA. Current understanding of the pathophysiology and approach to tension-type headache. Curr Neurol Neurosci Rep. 2021 doi: 10.1007/s11910-021-01138-7. - DOI - PubMed
    1. Koenig J, Williams DP, Kemp AH, Thayer JF. Vagally mediated heart rate variability in headache patients—a systematic review and meta-analysis. Cephalalgia. 2016 doi: 10.1177/0333102415583989. - DOI - PubMed