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. 2022 Nov:155:194-201.
doi: 10.1016/j.jpsychires.2022.08.019. Epub 2022 Aug 20.

Association between mental disorders and COVID-19 outcomes among inpatients in France: A retrospective nationwide population-based study

Alexandre Descamps  1 , Jérôme Frenkiel  2 , Kevin Zarca  2 , Charles Laidi  3 , Ophélia Godin  3 , Odile Launay  4 , Marion Leboyer  3 , Isabelle Durand-Zaleski  5
Affiliations

Association between mental disorders and COVID-19 outcomes among inpatients in France: A retrospective nationwide population-based study

Alexandre Descamps et al. J Psychiatr Res. 2022 Nov.

Abstract

Background: Mental disorders are at-risk of severe COVID-19 outcomes. There is limited and heterogeneous national data in hospital settings evaluating the risks associated with any pre-existing mental disorder, and susceptible subgroups. Our study aimed to investigate the association between pre-existing psychiatric disorders and outcomes of adults hospitalised for COVID-19.

Method: We used data obtained from the French national hospital database linked to the state-level psychiatric registry. The primary outcome was 30-days in-hospital mortality. Secondary outcomes were to compare the length of hospital stay, Intensive Care Unit (ICU) admission and ICU length. Propensity score matching analysis was used to control for COVID-19 confounding factors between patients with or without mental disorder and stratified by psychiatric subgroups.

Results: Among 97 302 adults hospitalised for COVID-19 from March to September 2020, 10 083 (10.3%) had a pre-existing mental disorder, mainly dementia (3581 [35.5%]), mood disorders (1298 [12.9%]), anxiety disorders (995 [9.9%]), psychoactive substance use disorders (960 [9.5%]), and psychotic disorders (866 [8.6%]). In propensity-matched analysis, 30-days in-hospital mortality was increased among those with at least one pre-existing mental disorder (hazard ratio (HR) 1.15, 95% CI 1.08-1.23), psychotic disorder (1.90, 1.24-2.90), and psychoactive substance disorders (1.53, 1.10-2.14). The odds of ICU admission were consistently decreased for patients with any pre-existing mental disorder (OR 0.83, 95% CI 0.76-0.92) and for those with dementia (0.64, 0.53-0.76).

Conclusion: Pre-existing mental disorders were independently associated with in-hospital mortality. These findings underscore the important need for adequate care and targeted interventions for at-risk individuals with severe mental illness.

Keywords: At-risk comorbidity; COVID-19 outcomes; ICU admission; In-hospital mortality; Mental disorders.

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Conflict of interest statement

Declaration of competing interest None.

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