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Review
. 2022 Dec;24(8):784-787.
doi: 10.1111/bdi.13256. Epub 2022 Sep 26.

Staging the bipolar disorders: Are early stages at too early a stage for intervention?

Affiliations
Review

Staging the bipolar disorders: Are early stages at too early a stage for intervention?

Gordon Parker. Bipolar Disord. 2022 Dec.

Abstract

Objectives: A number of staging models have been generated for the bipolar disorders, which include pre-onset as well as post-onset stages. Some models propose treatments for those at the pre-onset stage, a recommendation which is critiqued here.

Methods: Several exemplar staging models are overviewed, and a critique is provided.

Results: The critique argues against intervention at a pre-onset stage, in light of there being limited risk factors, unquantified sensitivity and specificity data for most putative onset illness risk factors, and thus there is the risk of overtreatment. Also, it is possible that many of the recommended interventions for those at risk of a bipolar disorder may have general non-specific benefits for those at risk.

Conclusions: While retaining a pre-onset phase in the staging model, it would appear wiser for it to not be populated with recommended interventions until they have a firmer empirical base.

Keywords: bipolar disorder; interventions; staging.

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Conflict of interest statement

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References

    1. Salagre E, Dodd S, Aedo A, et al. Toward precision psychiatry in bipolar disorder: staging 2.0. Front Psychiatry. 2018;9:641. - PMC - PubMed
    1. Fava GA, Kellner R. Staging: a neglected dimension in psychiatric classification. Acta Psychiatr Scand. 1993;87(4):225‐230. - PubMed
    1. McGorry PD, Hickie IB, Young AR, et al. Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventions. Aust N Z J Psychiatry. 2006;40(8):616‐622. - PubMed
    1. Berk M, Conus P, Lucas N, et al. Setting the stage: from prodrome to treatment resistance in bipolar disorder. Bipolar Disord. 2007;9(7):671‐678. - PubMed
    1. Berk M, Hallam KE, McGorry PD. The potential utility of a staging model as a course specifier: a bipolar disorder perspective. J Affect Disord. 2007;100(1–3):279‐281. - PubMed

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