Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct;26(19):4875-4885.
doi: 10.1111/jcmm.17518. Epub 2022 Sep 6.

Transcription factors are potential therapeutic targets in epilepsy

Qihan Sun  1 , Wenbo Xu  1 , Jingjing Piao  1 , Jingyun Su  1 , Tongtong Ge  1 , Ranji Cui  1 , Wei Yang  1 , Bingjin Li  1
Affiliations
Review

Transcription factors are potential therapeutic targets in epilepsy

Qihan Sun et al. J Cell Mol Med. 2022 Oct.

Abstract

Academics generally believe that imbalance between excitation and inhibition of the nervous system is the root cause of epilepsy. However, the aetiology of epilepsy is complex, and its pathogenesis remains unclear. Many studies have shown that epilepsy is closely related to genetic factors. Additionally, the involvement of a variety of tumour-related transcription factors in the pathogenesis of epilepsy has been confirmed, which also confirms the heredity of epilepsy. In this review, we summarize the existing research on a variety of transcription factors and epilepsy and present relevant evidence related to transcription factors that may be targets in epilepsy. This information is of great significance for revealing the in-depth molecular and cellular mechanisms of epilepsy.

Keywords: epilepsy; mechanism; transcription factors.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Diagram of the CREB relevant signalling pathways. AC, adenylate cyclase; AKT, protein kinase B; CAM, calmodulin; CAMK: CAM‐dependent protein kinase; cAMP, cyclic adenosine monophosphate; cGMP, cyclic guanosine monophosphate; ERK, extracellular‐regulated kinase; MSK, mitogen and stress‐activated protein kinase; p38MAPK, p38 mitogen activated protein kinases; PI3K, phosphoinositide 3‐kinase; PKA, protein kinase A; PKG, cGMP‐dependent protein kinase 1.
FIGURE 2
FIGURE 2
Diagram of the NFκB relevant signalling pathways. Bcl‐2, B‐cell lymphoma‐2; COX‐2, cyclooxygenase‐2; IKK, inhibitor of NFκB kinase; IL‐1β, interleukin 1 beta; iNOS, inducible nitric oxide synthase; IκB, inhibitor of NFκB; NFκB, nuclear factor kappa B; TNF‐α, tumourtumor necrosis factor‐α.
FIGURE 3
FIGURE 3
Diagram of the involvement of KLF4 in regulating the expression of multiple transcription factors. CREB, cAMP response element‐binding protein; IFN, interferon; IL‐1β, Interleukin 1 beta; IL‐6, interleukin 6; JAK, janus kinase; KLF4, Kkruüppel‐like factor 4; NFκB, nuclear factor kappa B; REST, repressor element 1‐silencing transcription; STAT3, signal transducer and activator of transcription 3.
See this image and copyright information in PMC

References

    1. Singh A, Trevick S. The epidemiology of global epilepsy. Neurol Clin. 2016;34(4):837‐847. doi:10.1016/j.ncl.2016.06.015 - DOI - PubMed
    1. Thijs RD, Surges R, O'Brien TJ, Sander JW. Epilepsy in adults. Lancet. 2019;393(10172):689‐701. doi:10.1016/S0140-6736(18)32596-0 - DOI - PubMed
    1. Ghaleb AM, Yang VW. Krüppel‐like factor 4 (KLF4): what we currently know. Gene. 2017;611:27‐37. doi:10.1016/j.gene.2017.02.025 - DOI - PMC - PubMed
    1. Yamamoto KK, Gonzalez GA, Biggs WH 3rd, Montminy MR. Phosphorylation‐induced binding and transcriptional efficacy of nuclear factor CREB. Nature. 1988;334(6182):494‐498. doi:10.1038/334494a0 - DOI - PubMed
    1. Silva AJ, Kogan JH, Frankland PW, Kida S. CREB and memory. Annu Rev Neurosci. 1998;21:127‐148. doi:10.1146/annurev.neuro.21.1.127 - DOI - PubMed

Publication types

Substances