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. 1987 Jun 30;145(3):1390-6.
doi: 10.1016/0006-291x(87)91592-0.

Influence of association and of positive inotropic drugs on calcium binding to cardiac troponin C

K Jaquet, L M Heilmeyer Jr

Influence of association and of positive inotropic drugs on calcium binding to cardiac troponin C

K Jaquet et al. Biochem Biophys Res Commun. .

Abstract

Isolated bovine cardiac troponin C forms dimers in presence of Mg2+ dependent on the protein concentration which has been determined by sedimentation velocity and sedimentation equilibrium. Dimer formation is correlated with a decrease in Ca2+ affinity. Positive inotropic drugs (benzimidazol derivatives) influence Ca2+ sensitivity either by changing the association state or by affecting the Ca2+ binding properties directly.

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