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. 1987 Aug 15;36(16):2633-6.
doi: 10.1016/0006-2952(87)90543-0.

The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani

S L Croft, R A Neal, W Pendergast, J H Chan

The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani

S L Croft et al. Biochem Pharmacol. .

Abstract

Several alkyl phosphorylcholines and related derivatives were tested against Leishmania donovani amastigotes in mouse peritoneal macrophages in vitro and ED50 values were determined in the range of 1-12 microM. The three alkyl phosphorylcholines tested against L. donovani in BALB/c mice were active, an ED50 of 12.8 mg/kg/day X 5 was ascertained for one compound, but an alkyl phosphorylethanolamine was inactive.

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