Review

. 2022 Dec;65(12):2354-2454.

doi: 10.1007/s11427-022-2161-3. Epub 2022 Sep 2.

The landscape of aging

Yusheng Cai^#^{1

2

3}, Wei Song^#⁴, Jiaming Li^#^{5

6}, Ying Jing^#^{6

7}, Chuqian Liang^#^{1

2

3}, Liyuan Zhang^#⁵, Xia Zhang^#⁸, Wenhui Zhang^#^{6

9}, Beibei Liu^#⁵, Yongpan An^#¹⁰, Jingyi Li^#^{1

2

3}, Baixue Tang^#¹¹, Siyu Pei^#⁸, Xueying Wu^#¹², Yuxuan Liu^#¹³, Cheng-Le Zhuang^#¹⁴, Yilin Ying^#^{15

16}, Xuefeng Dou^#⁸, Yu Chen^#¹⁷, Fu-Hui Xiao^#^{18

19}, Dingfeng Li^#²⁰, Ruici Yang^#²¹, Ya Zhao^#²², Yang Wang^#²³, Lihui Wang^#²⁴, Yujing Li^#^{1

2

3}, Shuai Ma^{25

26

27}, Si Wang^{28

29

30}, Xiaoyuan Song³¹, Jie Ren^{32

33

34}, Liang Zhang^{35

36}, Jun Wang^{37

38}, Weiqi Zhang^{39

40

41

42}, Zhengwei Xie⁴³, Jing Qu^{44

45

46}, Jianwei Wang⁴⁷, Yichuan Xiao⁴⁸, Ye Tian^{49

50}, Gelin Wang⁵¹, Ping Hu^{52

53

54}, Jing Ye^{55

56}, Yu Sun^{57

58}, Zhiyong Mao⁵⁹, Qing-Peng Kong^{60

61}, Qiang Liu^{62

63}, Weiguo Zou⁶⁴, Xiao-Li Tian⁶⁵, Zhi-Xiong Xiao⁶⁶, Yong Liu⁶⁷, Jun-Ping Liu^{68

69

70}, Moshi Song^{71

72

73

74}, Jing-Dong J Han⁷⁵, Guang-Hui Liu^{76

77

78

79

80

81}

Affiliations

¹ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
³ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
⁴ Frontier Science Center for Immunology and Metabolism, Medical Research Institute, College of Life Sciences, Wuhan University, Wuhan, 430071, China.
⁵ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.
⁶ University of Chinese Academy of Sciences, Beijing, 100049, China.
⁷ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
⁸ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China.
⁹ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
¹⁰ Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, 100191, China.
¹¹ School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
¹² State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
¹³ School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing, 100084, China.
¹⁴ Colorectal Cancer Center/Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, 200072, China.
¹⁵ Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
¹⁶ International Laboratory in Hematology and Cancer, Shanghai Jiaotong University School of Medicine/Ruijin Hospital, Shanghai, 200025, China.
¹⁷ Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
¹⁸ State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
¹⁹ CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China.
²⁰ Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
²¹ State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
²² Aging and Vascular Diseases, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang, 330031, China.
²³ Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, China.
²⁴ Institute of Ageing Research, Hangzhou Normal University, School of Basic Medical Sciences, Hangzhou, 311121, China.
²⁵ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. mashuai@ioz.ac.cn.
²⁶ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. mashuai@ioz.ac.cn.
²⁷ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. mashuai@ioz.ac.cn.
²⁸ Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. wangsi@xwh.ccmu.edu.cn.
²⁹ Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. wangsi@xwh.ccmu.edu.cn.
³⁰ The Fifth People's Hospital of Chongqing, Chongqing, 400062, China. wangsi@xwh.ccmu.edu.cn.
³¹ MOE Key Laboratory of Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, Neurodegenerative Disorder Research Center, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. songxy5@ustc.edu.cn.
³² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. renjie@big.ac.cn.
³³ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. renjie@big.ac.cn.
³⁴ University of Chinese Academy of Sciences, Beijing, 100049, China. renjie@big.ac.cn.
³⁵ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. zhangliang01@sibs.ac.cn.
³⁶ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. zhangliang01@sibs.ac.cn.
³⁷ University of Chinese Academy of Sciences, Beijing, 100049, China. junwang@im.ac.cn.
³⁸ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. junwang@im.ac.cn.
³⁹ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. zhangwq@big.ac.cn.
⁴⁰ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. zhangwq@big.ac.cn.
⁴¹ University of Chinese Academy of Sciences, Beijing, 100049, China. zhangwq@big.ac.cn.
⁴² Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. zhangwq@big.ac.cn.
⁴³ Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, 100191, China. xiezhengwei@hsc.pku.edu.cn.
⁴⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
⁴⁵ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. qujing@ioz.ac.cn.
⁴⁶ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
⁴⁷ School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China. jianweiwang@mail.tsinghua.edu.cn.
⁴⁸ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. ycxiao@sibs.ac.cn.
⁴⁹ University of Chinese Academy of Sciences, Beijing, 100049, China. ytian@genetics.ac.cn.
⁵⁰ State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China. ytian@genetics.ac.cn.
⁵¹ School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing, 100084, China. gelinwang@tsinghua.edu.cn.
⁵² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. hup@sibcb.ac.cn.
⁵³ Colorectal Cancer Center/Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, 200072, China. hup@sibcb.ac.cn.
⁵⁴ Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou, 510005, China. hup@sibcb.ac.cn.
⁵⁵ Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China. yj11254@rjh.com.cn.
⁵⁶ International Laboratory in Hematology and Cancer, Shanghai Jiaotong University School of Medicine/Ruijin Hospital, Shanghai, 200025, China. yj11254@rjh.com.cn.
⁵⁷ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. sunyu@sibs.ac.cn.
⁵⁸ Department of Medicine and VAPSHCS, University of Washington, Seattle, 98195, USA. sunyu@sibs.ac.cn.
⁵⁹ Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. zhiyong_mao@tongji.edu.cn.
⁶⁰ State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China. kongqp@mail.kiz.ac.cn.
⁶¹ CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China. kongqp@mail.kiz.ac.cn.
⁶² CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China. liuq2012@ustc.edu.cn.
⁶³ Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China. liuq2012@ustc.edu.cn.
⁶⁴ State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. zouwg94@sibcb.ac.cn.
⁶⁵ Aging and Vascular Diseases, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang, 330031, China. tianxiaoli@ncu.edu.cn.
⁶⁶ Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, China. jimzx@scu.edu.cn.
⁶⁷ Frontier Science Center for Immunology and Metabolism, Medical Research Institute, College of Life Sciences, Wuhan University, Wuhan, 430071, China. liuyong31279@whu.edu.cn.
⁶⁸ Institute of Ageing Research, Hangzhou Normal University, School of Basic Medical Sciences, Hangzhou, 311121, China. jun-ping.liu@monash.edu.
⁶⁹ Department of Immunology and Pathology, Monash University Faculty of Medicine, Prahran, Victoria, 3181, Australia. jun-ping.liu@monash.edu.
⁷⁰ Hudson Institute of Medical Research, and Monash University Department of Molecular and Translational Science, Clayton, Victoria, 3168, Australia. jun-ping.liu@monash.edu.
⁷¹ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
⁷² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
⁷³ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. songmoshi@ioz.ac.cn.
⁷⁴ University of Chinese Academy of Sciences, Beijing, 100049, China. songmoshi@ioz.ac.cn.
⁷⁵ Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology, Peking University, Beijing, 100871, China. jackie.han@pku.edu.cn.
⁷⁶ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
⁷⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
⁷⁸ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. ghliu@ioz.ac.cn.
⁷⁹ University of Chinese Academy of Sciences, Beijing, 100049, China. ghliu@ioz.ac.cn.
⁸⁰ Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.
⁸¹ Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.

^# Contributed equally.

PMID: 36066811
PMCID: PMC9446657
DOI: 10.1007/s11427-022-2161-3

Review

The landscape of aging

Yusheng Cai et al. Sci China Life Sci. 2022 Dec.

. 2022 Dec;65(12):2354-2454.

doi: 10.1007/s11427-022-2161-3. Epub 2022 Sep 2.

Authors

Affiliations

¹ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
³ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China.
⁴ Frontier Science Center for Immunology and Metabolism, Medical Research Institute, College of Life Sciences, Wuhan University, Wuhan, 430071, China.
⁵ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China.
⁶ University of Chinese Academy of Sciences, Beijing, 100049, China.
⁷ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
⁸ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China.
⁹ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
¹⁰ Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, 100191, China.
¹¹ School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
¹² State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
¹³ School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing, 100084, China.
¹⁴ Colorectal Cancer Center/Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, 200072, China.
¹⁵ Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
¹⁶ International Laboratory in Hematology and Cancer, Shanghai Jiaotong University School of Medicine/Ruijin Hospital, Shanghai, 200025, China.
¹⁷ Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
¹⁸ State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China.
¹⁹ CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China.
²⁰ Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China.
²¹ State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
²² Aging and Vascular Diseases, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang, 330031, China.
²³ Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, China.
²⁴ Institute of Ageing Research, Hangzhou Normal University, School of Basic Medical Sciences, Hangzhou, 311121, China.
²⁵ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. mashuai@ioz.ac.cn.
²⁶ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. mashuai@ioz.ac.cn.
²⁷ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. mashuai@ioz.ac.cn.
²⁸ Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. wangsi@xwh.ccmu.edu.cn.
²⁹ Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. wangsi@xwh.ccmu.edu.cn.
³⁰ The Fifth People's Hospital of Chongqing, Chongqing, 400062, China. wangsi@xwh.ccmu.edu.cn.
³¹ MOE Key Laboratory of Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, CAS Key Laboratory of Brain Function and Disease, Neurodegenerative Disorder Research Center, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230026, China. songxy5@ustc.edu.cn.
³² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. renjie@big.ac.cn.
³³ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. renjie@big.ac.cn.
³⁴ University of Chinese Academy of Sciences, Beijing, 100049, China. renjie@big.ac.cn.
³⁵ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. zhangliang01@sibs.ac.cn.
³⁶ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. zhangliang01@sibs.ac.cn.
³⁷ University of Chinese Academy of Sciences, Beijing, 100049, China. junwang@im.ac.cn.
³⁸ CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. junwang@im.ac.cn.
³⁹ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. zhangwq@big.ac.cn.
⁴⁰ CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, 100101, China. zhangwq@big.ac.cn.
⁴¹ University of Chinese Academy of Sciences, Beijing, 100049, China. zhangwq@big.ac.cn.
⁴² Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. zhangwq@big.ac.cn.
⁴³ Peking University International Cancer Institute, Peking University Health Science Center, Peking University, Beijing, 100191, China. xiezhengwei@hsc.pku.edu.cn.
⁴⁴ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
⁴⁵ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. qujing@ioz.ac.cn.
⁴⁶ State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. qujing@ioz.ac.cn.
⁴⁷ School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China. jianweiwang@mail.tsinghua.edu.cn.
⁴⁸ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. ycxiao@sibs.ac.cn.
⁴⁹ University of Chinese Academy of Sciences, Beijing, 100049, China. ytian@genetics.ac.cn.
⁵⁰ State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China. ytian@genetics.ac.cn.
⁵¹ School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing, 100084, China. gelinwang@tsinghua.edu.cn.
⁵² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. hup@sibcb.ac.cn.
⁵³ Colorectal Cancer Center/Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, 200072, China. hup@sibcb.ac.cn.
⁵⁴ Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou, 510005, China. hup@sibcb.ac.cn.
⁵⁵ Department of Geriatrics, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China. yj11254@rjh.com.cn.
⁵⁶ International Laboratory in Hematology and Cancer, Shanghai Jiaotong University School of Medicine/Ruijin Hospital, Shanghai, 200025, China. yj11254@rjh.com.cn.
⁵⁷ CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, 200031, China. sunyu@sibs.ac.cn.
⁵⁸ Department of Medicine and VAPSHCS, University of Washington, Seattle, 98195, USA. sunyu@sibs.ac.cn.
⁵⁹ Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China. zhiyong_mao@tongji.edu.cn.
⁶⁰ State Key Laboratory of Genetic Resources and Evolution/Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China. kongqp@mail.kiz.ac.cn.
⁶¹ CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China. kongqp@mail.kiz.ac.cn.
⁶² CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China. liuq2012@ustc.edu.cn.
⁶³ Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230027, China. liuq2012@ustc.edu.cn.
⁶⁴ State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. zouwg94@sibcb.ac.cn.
⁶⁵ Aging and Vascular Diseases, Human Aging Research Institute (HARI) and School of Life Science, Nanchang University, and Jiangxi Key Laboratory of Human Aging, Nanchang, 330031, China. tianxiaoli@ncu.edu.cn.
⁶⁶ Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment, Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, China. jimzx@scu.edu.cn.
⁶⁷ Frontier Science Center for Immunology and Metabolism, Medical Research Institute, College of Life Sciences, Wuhan University, Wuhan, 430071, China. liuyong31279@whu.edu.cn.
⁶⁸ Institute of Ageing Research, Hangzhou Normal University, School of Basic Medical Sciences, Hangzhou, 311121, China. jun-ping.liu@monash.edu.
⁶⁹ Department of Immunology and Pathology, Monash University Faculty of Medicine, Prahran, Victoria, 3181, Australia. jun-ping.liu@monash.edu.
⁷⁰ Hudson Institute of Medical Research, and Monash University Department of Molecular and Translational Science, Clayton, Victoria, 3168, Australia. jun-ping.liu@monash.edu.
⁷¹ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
⁷² Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. songmoshi@ioz.ac.cn.
⁷³ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. songmoshi@ioz.ac.cn.
⁷⁴ University of Chinese Academy of Sciences, Beijing, 100049, China. songmoshi@ioz.ac.cn.
⁷⁵ Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology, Peking University, Beijing, 100871, China. jackie.han@pku.edu.cn.
⁷⁶ State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
⁷⁷ Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ghliu@ioz.ac.cn.
⁷⁸ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing, 100101, China. ghliu@ioz.ac.cn.
⁷⁹ University of Chinese Academy of Sciences, Beijing, 100049, China. ghliu@ioz.ac.cn.
⁸⁰ Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.
⁸¹ Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital Capital Medical University, Beijing, 100053, China. ghliu@ioz.ac.cn.

^# Contributed equally.

PMID: 36066811
PMCID: PMC9446657
DOI: 10.1007/s11427-022-2161-3

Abstract

Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and cancer. Therefore, the growing emphasis on "healthy aging" raises a series of important questions in life and social sciences. In recent years, there has been unprecedented progress in aging research, particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes. In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases, we review the descriptive, conceptual, and interventive aspects of the landscape of aging composed of a number of layers at the cellular, tissue, organ, organ system, and organismal levels.

Keywords: aging; intervention; mechanism.

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Li A, Yan J, Zhao Y, Yu Z, Tian S, Khan AH, Zhu Y, Wu A, Zhang C, Tian XL. Li A, et al. Clin Interv Aging. 2023 Aug 17;18:1373-1395. doi: 10.2147/CIA.S423373. eCollection 2023. Clin Interv Aging. 2023. PMID: 37609042 Free PMC article. Review.
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References

1. Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton J P, Athineos D, Kang TW, Lasitschka F, Andrulis M, et al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol. 2013;15:978–990. doi: 10.1038/ncb2784. - DOI - PMC - PubMed
1. Acosta JC, O’Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, et al. Chemokine signaling via the CXCR2 receptor reinforces senescence. Cell. 2008;133:1006–1018. doi: 10.1016/j.cell.2008.03.038. - DOI - PubMed
1. Adams MM, Donohue HS, Linville MC, Iversen EA, Newton IG, Brunso-Bechtold JK. Age-related synapse loss in hippocampal CA3 is not reversed by caloric restriction. Neuroscience. 2010;171:373–382. doi: 10.1016/j.neuroscience.2010.09.022. - DOI - PMC - PubMed
1. Aghajanian H, Kimura T, Rurik JG, Hancock AS, Leibowitz MS, Li L, Scholler J, Monslow J, Lo A, Han W, et al. Targeting cardiac fibrosis with engineered T cells. Nature. 2019;573:430–433. doi: 10.1038/s41586-019-1546-z. - DOI - PMC - PubMed
1. Liu GH, Bao Y, Qu J, Zhang W, Zhang T, Kang W, Yang F, Ji Q, Jiang X, Ma Y, et al. Aging Atlas: a multi-omics database for aging biology. Nucl Acids Res. 2021;49:D825–D830. doi: 10.1093/nar/gkaa894. - DOI - PMC - PubMed

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