Myocarditis After BNT162b2 COVID-19 Third Booster Vaccine in Israel

Dror Mevorach^#^{1

2}, Emilia Anis^#^{2

3

4}, Noa Cedar^#^{3

4}, Tal Hasin^#^{2

5}, Michal Bromberg^{6

7}, Lital Goldberg^#^{3

4

8}, Nir Levi^#⁵, Ofer Perzon¹, Nur Magadle¹, Barhoum Barhoum¹, Elchanan Parnassa¹, Rita Dichtiar⁶, Yael Hershkovitz⁶, Manfred S Green⁹, Nachman Ash^{10

11}, Lital Keinan-Boker^#^{6

9}, Sharon Alroy-Preis^#¹¹

Affiliations

¹ Pnimit B & Division of Rheumatology-Immunology-Allergology and the Wohl Institute for Translational Medicine, Department of Medicine, Hadassah Medical Center, Jerusalem, Israel (D.M., O.P., N.M., B.B., E.P.).
² Faculty of Medicine, Hebrew University, Jerusalem, Israel (D.M., E.A., T.H.).
³ Division of Epidemiology, Israeli Ministry of Health, Jerusalem (E.A., N.C., L.G.).
⁴ Braun School of Public Health, Jerusalem, Israel (E.A., N.C., L.G.).
⁵ Jesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel (T.H., N.L.).
⁶ Israel Center for Disease Control, Ministry of Health, Ramat Gan, Israel (M.B., R.D., Y.H., L.K.-B.).
⁷ Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Israel (M.B.).
⁸ Clalit Health Services, Tel Aviv, Israel (L.G.).
⁹ School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Israel (M.S.G., L.K.-B.).
¹⁰ Department of Health Management, Ariel University, Jerusalem, Israel (N.A.).
¹¹ Israeli Ministry of Health, Jerusalem (N.A., S.A.-P.).

^# Contributed equally.

Dror Mevorach et al. Circulation. 2022.

. 2022 Sep 6;146(10):802-804.

doi: 10.1161/CIRCULATIONAHA.122.060961. Epub 2022 Sep 6.

¹ Pnimit B & Division of Rheumatology-Immunology-Allergology and the Wohl Institute for Translational Medicine, Department of Medicine, Hadassah Medical Center, Jerusalem, Israel (D.M., O.P., N.M., B.B., E.P.).
² Faculty of Medicine, Hebrew University, Jerusalem, Israel (D.M., E.A., T.H.).
³ Division of Epidemiology, Israeli Ministry of Health, Jerusalem (E.A., N.C., L.G.).
⁴ Braun School of Public Health, Jerusalem, Israel (E.A., N.C., L.G.).
⁵ Jesselson Integrated Heart Center, Shaare Zedek Medical Center, Jerusalem, Israel (T.H., N.L.).
⁶ Israel Center for Disease Control, Ministry of Health, Ramat Gan, Israel (M.B., R.D., Y.H., L.K.-B.).
⁷ Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Israel (M.B.).
⁸ Clalit Health Services, Tel Aviv, Israel (L.G.).
⁹ School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Israel (M.S.G., L.K.-B.).
¹⁰ Department of Health Management, Ariel University, Jerusalem, Israel (N.A.).
¹¹ Israeli Ministry of Health, Jerusalem (N.A., S.A.-P.).

^# Contributed equally.

No abstract available

Keywords: BNT162 vaccine; drug-related side effects and adverse reactions; immunization, secondary; mRNA vaccines; myocarditis.

References

1. Levin EG, Lustig Y, Cohen C, Fluss R, Indenbaum V, Amit S, Doolman R, Asraf K, Mendelson E, Ziv A, et al. . Waning immune humoral response to BNT162b2 COVID-19 vaccine over 6 months. N Engl J Med. 2021;385:e84. doi: 10.1056/NEJMoa2114583 - PMC - PubMed
1. Mevorach D, Anis E, Cedar N, Hasin T, Bromberg M, Goldberg L, Parnasa E, Dichtiar R, Hershkovitz Y, Ash N, et al. . Myocarditis after BNT162b2 vaccination in Israeli adolescents. N Engl J Med. 2022;386:998–999. doi: 10.1056/NEJMc2116999 - PMC - PubMed
1. Mevorach D, Anis E, Cedar N, Bromberg M, Haas EJ, Nadir E, Olsha-Castell S, Arad D, Hasin T, Levi N, et al. . Myocarditis after BNT162b2 mRNA vaccine against COVID-19 in Israel. N Engl J Med. 2021;385:2140–2149. doi: 10.1056/NEJMoa2109730 - PMC - PubMed
1. Tauzin A, Gong SY, Beaudoin-Bussières G, Vézina D, Gasser R, Nault L, Marchitto L, Benlarbi M, Chatterjee D, Nayrac M, et al. . Strong humoral immune responses against SARS-CoV-2 spike after BNT162b2 mRNA vaccination with a sixteen-week interval between doses. medRxiv. Preprint posted online September 21, 2021. doi: 10.1101/2021.09.17.21263532 - PMC - PubMed
1. Zhang C, Maruggi G, Shan H, Li J. Advances in mRNA vaccines for infectious diseases. Front Immunol. 2019;10:594. doi: 10.3389/fimmu.2019.00594 - PMC - PubMed