Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 Sep 6;12(1):15125.
doi: 10.1038/s41598-022-19508-7.

12-month prevalence of atopic dermatitis in resource-rich countries: a systematic review and meta-analysis

Annika Volke  1   2 , Karolin Toompere  3 , Kaja-Triin Laisaar  3 , Marje Oona  3 , Anna Tisler  3 , Annika Johannson  3   4 , Kadi Kallavus  3 , Katrin Lang  3 , Ele Kiisk  3 , Anneli Uusküla  5   3
Affiliations
Meta-Analysis

12-month prevalence of atopic dermatitis in resource-rich countries: a systematic review and meta-analysis

Annika Volke et al. Sci Rep. .

Abstract

There is a lack of robust prevalence estimates of atopic dermatitis (AD) globally and trends over time due to wide variation of populations and age groups studied, different study methodologies and case definitions used. We sought to characterize 12-month AD prevalence across the life span and change over time in resource-rich countries focusing on population-based studies and using a standardized AD case definition. This systematic review was conducted according to PRISMA guidelines. Medline (Ovid), Embase, WOS core collection, Cinahl, and Popline were searched for studies published since inception through August 15, 2016. Studies were synthesized using random effects meta-analysis. Sources of heterogeneity were investigated using subgroup analyses and meta-regression. From 12,530 records identified, 45 studies met the inclusion criteria. Meta-analysis with random effects revealed the 12-month period prevalence of 9.2% (95% confidence interval 8.4-10.1%). The prevalence was significantly higher among 0-5-year-old children (16.2%; 95% confidence interval 14.2-18.7%) than in older age groups. Studies using a random sampling strategy yielded lower prevalence estimates than studies relying on other sampling methods. There was no clear time trend in AD prevalence over the period of 1992-2013.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
The study selection process for the systematic review and meta-analysis.
Figure 2
Figure 2
Risk of bias assessment.
Figure 3
Figure 3
12-month prevalence of AD across age groups.
Figure 4
Figure 4
12-month prevalence of AD by age groups (0–5, 6–12, 13–18 and 19 + years) and region over time.
See this image and copyright information in PMC

References

    1. Drucker AM, Wang AR, Li WQ, Sevetson E, Block JK, Qureshi AA. The burden of atopic dermatitis: Summary of a report for the National Eczema Association. J. Invest. Dermatol. 2017;137:26–30. doi: 10.1016/j.jid.2016.07.012. - DOI - PubMed
    1. Silverberg JI, Gelfand JM, Margolis DJ, Simpson EL, Ong PY, Fuxench ZCC. Patient burden and quality of life in atopic dermatitis in US adults: a population-based cross-sectional study. Ann. Allergy Asthma Immunol. 2018;121:340–347. doi: 10.1016/j.anai.2018.07.006. - DOI - PubMed
    1. Urban K, Chu S, Giesey RL, Mehrmal S, Uppal P, Nedley N, et al. The global, regional, and national burden of atopic dermatitis in 195 countries and territories: An ecological study from the Global Burden of Disease Study 2017. JAAD Int. 2021;2:12–18. doi: 10.1016/j.jdin.2020.10.002. - DOI - PMC - PubMed
    1. Laughter MR, Maymone MBC, Mashayekhi S, Arents BWM, Karimkhani C, Langan SL, et al. The global burden of atopic dermatitis: Lessons from the Global Burden of Disease Study 1990–2017. Br. J. Dermatol. 2021;184:304–309. doi: 10.1111/bjd.19580. - DOI - PubMed
    1. Deleuran M, Vestergaard C. Clinical heterogeneity and differential diagnosis of atopic dermatitis. Br. J. Dermatol. 2014;170(Suppl 1):2–6. doi: 10.1111/bjd.12933. - DOI - PubMed

Publication types