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Review
. 2022:2547:47-61.
doi: 10.1007/978-1-0716-2573-6_3.

Pharmacogenomics in Targeted Therapy and Supportive Care Therapies for Cancer

Zahra Talebi  1 , Alex Sparreboom  2 , Susan I Colace  3   4
Affiliations
Review

Pharmacogenomics in Targeted Therapy and Supportive Care Therapies for Cancer

Zahra Talebi et al. Methods Mol Biol. 2022.

Abstract

Targeted therapies have significantly altered the landscape of available cancer therapies across all diagnoses and patient populations, and supportive care therapies have steadily improved throughout the years to make therapy more tolerable for patients. Even so, these therapies have varied efficacy and toxicity among patients with cancer, and pharmacogenomics presents an opportunity to identify which patients are most at risk of toxicities and most likely to benefit from them. While the field of pharmacogenomics in targeted cancer therapy is still growing, we review current knowledge, hypotheses, and clinical practices in this chapter, along with a brief review of pharmacogenomics in supportive therapies in cancer treatment.

Keywords: Cancer; Chemotherapy; Efficacy; Pharmacogenomics; Targeted therapies; Toxicity.

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References

    1. Talebi Z, Baker SD, Sparreboom A (2023) Pharmacology of small-molecule anticancer agents. In: Bast RC Jr, Byrd J, Croce CM(eds) Holland-Frei cancer medicine, 10th edn. Wiley Blackwell, USA
    1. Schneider BP, Wang M, Radovich M et al (2008) Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100. J Clin Oncol 26(28):4672–4678 - DOI - PubMed - PMC
    1. Udagawa C, Zembutsu H (2020) Pharmacogenetics for severe adverse drug reactions induced by molecular-targeted therapy. Cancer Sci 111(10):3445–3457 - DOI - PubMed - PMC
    1. Diasio RB, Innocenti F, Offer SM (2021) Pharmacogenomic-guided therapy in colorectal cancer. Clin Pharmacol Ther 110(3):616–625 - DOI - PubMed
    1. Dulucq S, Bouchet S, Turcq B et al (2008) Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia. Blood 112(5):2024–2027 - DOI - PubMed

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