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Review
. 2022:2547:63-94.
doi: 10.1007/978-1-0716-2573-6_4.

Pharmacogenomics in Cytotoxic Chemotherapy of Cancer

Zahra Talebi  1 , Alex Sparreboom  2 , Susan I Colace  3   4
Affiliations
Review

Pharmacogenomics in Cytotoxic Chemotherapy of Cancer

Zahra Talebi et al. Methods Mol Biol. 2022.

Abstract

Pharmacogenetic testing in patients with cancer requiring cytotoxic chemotherapy offers the potential to predict, prevent, and mitigate chemotherapy-related toxicities. While multiple drug-gene pairs have been identified and studied, few drug-gene pairs are currently used routinely in the clinical status. Here we review what is known, theorized, and unknown regarding the use of pharmacogenetic testing in cancer.

Keywords: Cancer; Chemotherapy; Efficacy; Pharmacogenetics; Pharmacogenomics; Toxicity.

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