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Review
. 2022 Sep 7;78(1-2):9-25.
doi: 10.1515/znc-2022-0076. Print 2023 Jan 27.

Santalum Genus: phytochemical constituents, biological activities and health promoting-effects

Javad Sharifi-Rad  1 , Cristina Quispe  2 , Aknur Turgumbayeva  3   4 , Zehra Mertdinç  5 , Sena Tütüncü  5 , Elif Feyza Aydar  5 , Beraat Özçelik  5   6 , Stępień-Warda Anna  7 , Staniak Mariola  7 , Anna Koziróg  8 , Anna Otlewska  8 , Hubert Antolak  8 , Surjit Sen  9   10 , Krishnendu Acharya  10 , Natallia Lapava  11 , Simin Emamzadeh-Yazdi  12 , Miquel Martorell  13   14 , Manoj Kumar  15 , Elena Maria Varoni  16   17 , Marcello Iriti  17   18 , Daniela Calina  19
Affiliations
Free article
Review

Santalum Genus: phytochemical constituents, biological activities and health promoting-effects

Javad Sharifi-Rad et al. Z Naturforsch C J Biosci. .
Free article

Abstract

Santalum genus belongs to the family of Santalaceae, widespread in India, Australia, Hawaii, Sri Lanka, and Indonesia, and valued as traditional medicine, rituals and modern bioactivities. Sandalwood is reported to possess a plethora of bioactive compounds such as essential oil and its components (α-santalol and β-santalol), phenolic compounds and fatty acids. These bioactives play important role in contributing towards biological activities and health-promoting effects in humans. Pre-clinical and clinical studies have shown the role of sandalwood extract as antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, neuroleptic, antihyperglycemic, antihyperlipidemic, and anticancer activities. Safety studies on sandalwood essential oil (EO) and its extracts have proven them as a safe ingredient to be utilized in health promotion. Phytoconstituents, bioactivities and traditional uses established sandalwood as one of the innovative materials for application in the pharma, food, and biomedical industry.

Keywords: bioactivities; clinical studies; essential oil; phytochemistry; safety; sandalwood.

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References

    1. Subasinghe, U. Sandalwood research: a global perspective. J Trop For Environ 2013;3:1–8. https://doi.org/10.31357/jtfe.v3i1.1117.
    1. Fox, J. Sandalwood: the royal tree. Biologist 2000;47:31. https://doi.org/10.7748/ns.14.52.31.s51.
    1. Harbaugh, DT, Baldwin, BG. Phylogeny and biogeography of the sandalwoods (Santalum, Santalaceae): repeated dispersals throughout the Pacific. Am J Bot 2007;94:1028–40. https://doi.org/10.3732/ajb.94.6.1028.
    1. Harbaugh, D. A taxonomic revision of Australian northern sandalwood (Santalum lanceolatum, Santalaceae). Aust Syst Bot 2007;20:409–16. https://doi.org/10.1071/sb07009.
    1. Harbaugh, DT, Oppenheimer, HL, Wood, KR, Wagner, WL. Taxonomic revision of the endangered Hawaiian red-flowered sandalwoods (Santalum) and discovery of an ancient hybrid species. Syst Bot 2010;35:827–38. https://doi.org/10.1600/036364410x539899.

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