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. 2022 Sep 22;387(12):1141-1143.
doi: 10.1056/NEJMc2209371. Epub 2022 Sep 7.

Effects of Vaccination and Previous Infection on Omicron Infections in Children

Dan-Yu Lin  1 , Yu Gu  1 , Yangjianchen Xu  1 , Donglin Zeng  1 , Bradford Wheeler  2 , Hayley Young  2 , Shadia Khan Sunny  2 , Zack Moore  2
Affiliations

Effects of Vaccination and Previous Infection on Omicron Infections in Children

Dan-Yu Lin et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Protection Conferred by Two Doses of BNT162b2 Vaccine and by Previous Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection against Infection and Coronavirus Disease 2019–Related Hospitalization in Children 5 to 11 Years of Age.
The estimated effectiveness of the BNT162b2 vaccine against SARS-CoV-2 infection is shown as a function of time since the first dose, according to the date of the first dose (Panel A; each curve starts at the median date of the first dose) and according to previous infection status (Panel B). The estimated effectiveness of previous SARS-CoV-2 infection against reinfection is shown as a function of time since previous infection, according to the variant type, among unvaccinated children (Panel C) and among vaccinated children (Panel D). In Panels C and D, for each type of previous infection, the curve starts at the median date of the initial diagnosis plus 2 weeks. For variants before delta, the range of these dates is March 11, 2020, to June 30, 2021; for delta, July 1 to December 15, 2021; and for omicron, December 16, 2021, to June 3, 2022. Panel E shows the estimated vaccine effectiveness against hospitalization, and Panel F shows the estimated effectiveness of previous infection against hospitalization due to reinfection. In Panels B, C, and D, effectiveness is calculated for one exposure alone (vaccination or previous infection), given the status of the other exposure. The shaded bands indicate 95% confidence intervals.
See this image and copyright information in PMC

Comment in

  • More on Omicron Infections in Children.
    Ladhani SN, Amirthalingam G, Khalil A. Ladhani SN, et al. N Engl J Med. 2022 Nov 17;387(20):1911. doi: 10.1056/NEJMc2212691. N Engl J Med. 2022. PMID: 36383727 No abstract available.

References

    1. Food and Drug Administration. FDA authorizes Pfizer–BioNTech COVID-19 vaccine for emergency use in children 5 through 11 years of age. October 29, 2021. (https://www.fda.gov/news-events/press-announcements/fda-authorizes-pfize...).
    1. Cohen-Stavi CJ, Magen O, Barda N, et al. BNT162b2 vaccine effectiveness against omicron in children 5 to 11 years of age. N Engl J Med 2022;387:227-236. - PMC - PubMed
    1. Fleming-Dutra KE, Britton A, Shang N, et al. Association of prior BNT162b2 COVID-19 vaccination with symptomatic SARS-CoV-2 infection in children and adolescents during omicron predominance. JAMA 2022;327:2210-2219. - PMC - PubMed
    1. Price AM, Olson SM, Newhams MM, et al. BNT162b2 protection against the omicron variant in children and adolescents. N Engl J Med 2022;386:1899-1909. - PMC - PubMed
    1. Lin D-Y, Gu Y, Wheeler B, et al. Effectiveness of Covid-19 vaccines over a 9-month period in North Carolina. N Engl J Med 2022;386:933-941. - PMC - PubMed

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Supplementary concepts