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Review
. 2022 Aug:69 Suppl 3:e29273.
doi: 10.1002/pbc.29273.

How we approach complex vascular anomalies and overgrowth syndromes

Katherine D Watson  1 , Kyung R Kim  2 , Julie Blatt  3
Affiliations
Review

How we approach complex vascular anomalies and overgrowth syndromes

Katherine D Watson et al. Pediatr Blood Cancer. 2022 Aug.

Abstract

Vascular anomalies, both vascular tumors and vascular malformations, can occur in isolation or as part of syndromes including those which feature phenotypic overgrowth. To update what is known about vascular anomalies associated with overgrowth, PubMed was searched for "overgrowth syndromes and vascular anomalies or malformations." PubMed, OMIM, and the Rare Disease Database also were searched for specific diagnoses. We review individual overgrowth syndromes, provide a case-based approach to the clinical, radiographic, pathologic, and genetic basis for diagnosis, to complications of both the vascular anomalies and the overgrowth, and emphasize the need for a multidisciplinary approach to care.

Keywords: PIK3CA; overgrowth; vascular malformations.

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References

REFERENCES

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