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. 2022 Nov 1;75(5):553-555.
doi: 10.1097/MPG.0000000000003603. Epub 2022 Sep 6.

Hepatitis-associated Aplastic Anemia

Maxime Gonnot  1 , Florent Neumann  2 , Frédéric Huet  1 , Raphaëlle Maudinas  1 , Thierry Leblanc  3 , Florence Lacaille  4
Affiliations

Hepatitis-associated Aplastic Anemia

Maxime Gonnot et al. J Pediatr Gastroenterol Nutr. .

Abstract

Hepatitis-associated aplastic anemia (HAAA) accounts for 4% of autoimmune hepatitis in children. An episode of seronegative autoimmune hepatitis is followed a few days or months later by aplastic anemia or full aplasia. This autoimmune disease could be due to a regulation defect in the immune response to a viral trigger, in a genetically predisposed individual. Other causes of hepatitis or aplastic anemia have to be ruled out. Steroids and azathioprine usually control the liver damage but do not prevent the development of aplastic anemia. Aplastic anemia is treated with either hematopoietic stem cell transplantation in patients with a sibling donor or anti-thymocyte globulins and cyclosporine. We propose guidelines to explore and treat this rare disease. We emphasize on the necessary close collaboration between hepatologists and hematologists.

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Conflict of interest statement

The authors report no conflicts of interest.

References

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