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Comment
. 2022 Sep 6;34(9):1227-1229.
doi: 10.1016/j.cmet.2022.08.013.

Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration

Matheus B Victor  1 , Li-Huei Tsai  2
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Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration

Matheus B Victor et al. Cell Metab. .
Free article

Abstract

In this issue of Cell Metabolism, Traxler et al. report a metabolic switch in neurons that hinges on the critical balance of pyruvate kinase M (PKM) isoform ratios. Using directly induced neurons (iNs) derived from patients with Alzheimer's disease (AD), the work delineates the impact of an AD-specific switch from PKM1 to PKM2 onto neuronal resilience against neurodegeneration.

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Declaration of interests The authors declare no competing interests.

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