Methionine restriction forces Epstein-Barr virus out of latency

Sriraksha Bharadwaj Kashyap¹, Racheal Mulondo¹, Peter J Mullen²

Affiliations

¹ Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
² Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles CA 90089, USA. Electronic address: petermul@usc.edu.

PMID: 36070678
DOI: 10.1016/j.cmet.2022.08.009

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Methionine restriction forces Epstein-Barr virus out of latency

Sriraksha Bharadwaj Kashyap et al. Cell Metab. 2022.

Free article

. 2022 Sep 6;34(9):1229-1231.

doi: 10.1016/j.cmet.2022.08.009.

Authors

Sriraksha Bharadwaj Kashyap¹, Racheal Mulondo¹, Peter J Mullen²

Affiliations

¹ Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
² Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles CA 90089, USA. Electronic address: petermul@usc.edu.

PMID: 36070678
DOI: 10.1016/j.cmet.2022.08.009

Abstract

EBV gene expression is repressed during viral latency to prevent an immune response, but it is not known how metabolism contributes to this silencing. In this issue of Cell Metabolism, Guo et al. describe how methionine restriction reactivates the expression of EBV genes, offering new therapeutic approaches against EBV-driven diseases.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

Methionine metabolism controls the B cell EBV epigenome and viral latency.
Guo R, Liang JH, Zhang Y, Lutchenkov M, Li Z, Wang Y, Trujillo-Alonso V, Puri R, Giulino-Roth L, Gewurz BE. Guo R, et al. Cell Metab. 2022 Sep 6;34(9):1280-1297.e9. doi: 10.1016/j.cmet.2022.08.008. Cell Metab. 2022. PMID: 36070681 Free PMC article.

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Methionine restriction forces Epstein-Barr virus out of latency

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Methionine restriction forces Epstein-Barr virus out of latency

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Abstract

Conflict of interest statement

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