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Randomized Controlled Trial
. 2023 Jan;270(1):357-368.
doi: 10.1007/s00415-022-11362-x. Epub 2022 Sep 7.

Rehabilitation effects in idiopathic normal pressure hydrocephalus: a randomized controlled trial

Yasutaka Nikaido  1 , Hideyuki Urakami  2 , Yohei Okada  3   4 , Toshihiro Akisue  5 , Yuki Kawami  5   6 , Naoya Ishida  2 , Yoshinaga Kajimoto  7 , Ryuichi Saura  8
Affiliations
Randomized Controlled Trial

Rehabilitation effects in idiopathic normal pressure hydrocephalus: a randomized controlled trial

Yasutaka Nikaido et al. J Neurol. 2023 Jan.

Abstract

Background: Gait-balance disturbances are core symptoms of idiopathic normal pressure hydrocephalus (iNPH). However, the rehabilitation effects of cerebrospinal fluid (CSF) shunting along with other treatment or no further treatment (natural course [NC]) for iNPH are unknown.

Objectives: This study evaluated whether dynamic equilibrium gait training (DEGT) can improve gait-balance functions after CSF shunting of patients with iNPH compared to standard exercise (SE) and NC. Furthermore, it investigated the incidence of falls.

Methods: A total of 70 patients with iNPH who underwent CSF shunting were randomly assigned to 6 weeks of DEGT (n = 23), 6 weeks of SE (n = 23), or NC (n = 24). Evaluation was performed at baseline (preoperatively) and at 1 week, 7 weeks (postintervention), and 6 months postoperatively (follow-up). Outcomes were measured using the functional gait assessment (FGA), 10-m walk test, timed up-and-go test, life-space assessment (LSA), and fall incidence.

Results: A total of 65 participants completed the study. During the intention-to-treat analysis, the DEGT group demonstrated significant recovery of gait-balance functions according to only the FGA at postintervention and follow-up compared to the SE and NC groups; however, recovery of the SE group did not differ from that of the NC group. The DEGT group had a significantly lower fall incidence than the other groups at follow-up. Significantly better LSA results were observed for all groups at follow-up compared to baseline; however, no difference in LSA results were observed between groups.

Conclusions: DEGT in addtion to CSF shunting can facilitate the recovery of gait-balance function and reduce the fall incidence of iNPH patients.

Keywords: Gait; Hydrocephalus; Neurological rehabilitation; Physical therapy modalities; Rehabilitation.

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