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. 2022 Sep 1;9(Pt 5):536-537.
doi: 10.1107/S2052252522008685.

To bind, or not to bind, that is the question…

Wayne F Anderson  1
Affiliations

To bind, or not to bind, that is the question…

Wayne F Anderson. IUCrJ. .

Abstract

The unexpected findings that are described by Czub et al. [IUCrJ (2022), 9, 551-561] provide a very interesting study demonstrating how small differences in structure can result in significant changes in the relative affinities of the seemingly promiscuous binding sites that are seen with serum albumins.

Keywords: NSAIDs; anti-inflammatory drugs; drug interactions; drug transport; human serum albumin; ketoprofen; organism-dependent studies.

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Figures

Figure 1
Figure 1
The ketoprofen binding sites from various organisms.
See this image and copyright information in PMC

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References

    1. Czub, M. P., Stewart, A. J., Shabalin, I. G. & Minor, W. (2022). IUCrJ, 9, 551–561. - PMC - PubMed
    1. Czub, M. P., Handing, K. B., Venkataramany, B. S., Cooper, D. R., Shabalin, I. G. & Minor, W. (2020). J. Med. Chem. 63, 6847–6862. - PMC - PubMed
    1. Tanford, C. (1961). Physical Chemistry of Macromolecules. New York: John Wiley and Sons.