Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Sep 1;9(Pt 5):536-537.
doi: 10.1107/S2052252522008685.

To bind, or not to bind, that is the question…

Wayne F Anderson  1
Affiliations

To bind, or not to bind, that is the question…

Wayne F Anderson. IUCrJ. .

Abstract

The unexpected findings that are described by Czub et al. [IUCrJ (2022), 9, 551-561] provide a very interesting study demonstrating how small differences in structure can result in significant changes in the relative affinities of the seemingly promiscuous binding sites that are seen with serum albumins.

Keywords: NSAIDs; anti-inflammatory drugs; drug interactions; drug transport; human serum albumin; ketoprofen; organism-dependent studies.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The ketoprofen binding sites from various organisms.
See this image and copyright information in PMC

References

    1. Czub, M. P., Stewart, A. J., Shabalin, I. G. & Minor, W. (2022). IUCrJ, 9, 551–561. - PMC - PubMed
    1. Czub, M. P., Handing, K. B., Venkataramany, B. S., Cooper, D. R., Shabalin, I. G. & Minor, W. (2020). J. Med. Chem. 63, 6847–6862. - PMC - PubMed
    1. Tanford, C. (1961). Physical Chemistry of Macromolecules. New York: John Wiley and Sons.