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. 2022 Aug 28:2022:4560609.
doi: 10.1155/2022/4560609. eCollection 2022.

Investigating Causal Relations between Genetic-Related Intermediate Endophenotype and Risk of Chronic Prostatitis: Mendelian Randomization Study

Shengfeng Zhang  1   2   3 , Xing Xie  1 , Lei Yu  1 , Nili Jiang  1 , Xihuan Wei  1 , Yanling Hu  1
Affiliations

Investigating Causal Relations between Genetic-Related Intermediate Endophenotype and Risk of Chronic Prostatitis: Mendelian Randomization Study

Shengfeng Zhang et al. Oxid Med Cell Longev. .

Abstract

Objective: Prostatitis is a common disease of the male genitourinary system, which seriously disturbs the physical and mental health of male patients. It is related to many factors such as living habits, age, and race, but the etiology has not been fully elucidated. This study investigated whether there is a causal relationship between clinical biochemical indicators (i.e., intermediate phenotype) and prostatitis through Mendelian randomization. The subjects of the study were prostatitis patients and related SNPs in the Guangxi Fangchenggang health examination cohort.

Methods: According to the requirements of Mendelian randomization (MR), the single nucleotide polymorphisms (SNPs) related to prostatitis patients and 29 common SNPs related to clinical biochemical indicators were analyzed by linkage disequilibrium, and the calculated SNPs were selected. Finally, the related SNPs were analyzed by Mendelian randomization method.

Results: 15 biochemical indicators such as complement C4, FOL, CRP, HCY, and estradiol have shared chronic prostatitis SNP sites, and five qualified SNPs were finally screened for complement C4. Finally, complement C4 was obtained by Mendelian randomization method (P = 0.039), which was statistically significant. The other 28 clinical endophenotypes were all negative.

Conclusion: The results show that there was a causal relationship between complement C4 and prostatitis, and the more consistent SNP is rs2075799.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Results of Mendelian randomization method for complement C4 and chronic prostatitis (CP).
Figure 2
Figure 2
IVW, MR-Egger regression, and WM scatter plot to study the effect of C4 on CP.
Figure 3
Figure 3
Sensitivity analysis of the leave-one-out method.
See this image and copyright information in PMC

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