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. 2022 Aug 17:2022:8089914.
doi: 10.1155/2022/8089914. eCollection 2022.

Efficacy Analysis of Double-Low Dynamic Contrast-Enhanced CT and Hepatic Extracellular Volume Fraction in the Diagnosis of Liver Fibrosis

Zhandong Liang  1 , Yanxia Liu  2 , Yuanwen Nie  3
Affiliations

Efficacy Analysis of Double-Low Dynamic Contrast-Enhanced CT and Hepatic Extracellular Volume Fraction in the Diagnosis of Liver Fibrosis

Zhandong Liang et al. Contrast Media Mol Imaging. .

Abstract

Objective: The aim of the study was to analyze the efficacy of double-low dynamic contrast-enhanced CT (DCE-CT) and hepatic extracellular volume fraction (fECV) in the diagnosis of liver fibrosis (LF).

Methods: A total of 200 patients with LF and cirrhosis who underwent the histopathological examination of liver biopsy and multiphase DCE-CT of the liver at the same time in our hospital (January 2020-December 2020) were selected as the research subjects, and the degree of liver fibrosis was staged according to pathological criteria to analyze the clinical diagnostic value of double-low DCE-CT and fECV.

Results: Compared with the S2-S4 group, the S1 group had obviously higher Eaorta and HCT values (P < 0.05), a lower fECV value (P < 0.001), and lower serum IVC and LN levels (P < 0.001). Serum IVC and LN levels were positively correlated with fECV (r 1 = 0.803 and r 2 = 0.890; P < 0.001). The fECV had the highest specificity and negative predictive value in the diagnosis of S1 and had the highest sensitivity and positive predictive value in the diagnosis of S2-S4.

Conclusion: The double-low DCE-CT and fECV can provide a reliable basis for the clinical diagnosis of LF, and their results will provide a new direction for the treatment of LF and have a high application value in the clinical practice.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of the study.
Figure 2
Figure 2
Note: (a) an image of S1; (b) an image of S2; (c) an image of S3; (d) an image of S4.
Figure 3
Figure 3
Spearman correlation analysis between fECV and serological indicators. Note: (a) correlation analysis between the IVC level and fECV and (b) correlation analysis between the LN level and fECV.
Figure 4
Figure 4
ROC curves of fECV for LF diagnosis at each stage. Note: (a) ROC curve of S1 diagnosis; (b) ROC curve of S2–4 diagnosis; (c) ROC curve of S3-4 diagnosis; (d) ROC curve of S4 diagnosis.
See this image and copyright information in PMC

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