Comparison of the Risk of Recurrent Clostridioides Difficile Infections Among Patients in 2018 Versus 2013

Alice Y Guh¹, Sarah H Yi¹, James Baggs¹, Lisa Winston², Erin Parker³, Helen Johnston⁴, Elizabeth Basiliere⁴, Danyel Olson⁵, Scott K Fridkin⁶, Nirja Mehta⁶, Lucy Wilson⁷, Rebecca Perlmutter⁸, Stacy M Holzbauer^{9

10}, Paige D'Heilly⁹, Erin C Phipps¹¹, Kristina G Flores¹¹, Ghinwa K Dumyati¹², Trupti Hatwar¹², Rebecca Pierce¹³, Valerie L S Ocampo¹³, Christopher D Wilson¹⁴, Jasmine J Watkins¹⁴, Lauren Korhonen¹, Ashley Paulick¹, Michelle Adamczyk¹, Dale N Gerding¹⁵, Sujan C Reddy¹

Affiliations

¹ Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
² Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California, USA.
³ California Emerging Infections Program, Oakland, California, USA.
⁴ Colorado Department of Public Health and Environment, Denver, Colorado, USA.
⁵ Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut, USA.
⁶ Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
⁷ Department of Emergency Health Services, University of Maryland Baltimore County, Baltimore, Maryland, USA.
⁸ Maryland Department of Health, Baltimore, Maryland, USA.
⁹ Minnesota Department of Health, St. Paul, Minnesota, USA.
¹⁰ Career Epidemiology Field Officer Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
¹¹ New Mexico Emerging Infections Program, University of New Mexico, Albuquerque, New Mexico, USA.
¹² Department of Medicine, New York Emerging Infections Program and University of Rochester Medical Center, Rochester, New York, USA.
¹³ Oregon Health Authority, Portland, Oregon, USA.
¹⁴ Tennessee Department of Health, Nashville, Tennessee, USA.
¹⁵ Departments of Medicine and Research, Edward Hines, Jr. Veterans Affairs Hospital, Hines, Illinois, USA.

PMID: 36072699
PMCID: PMC9439575
DOI: 10.1093/ofid/ofac422

Comparison of the Risk of Recurrent Clostridioides Difficile Infections Among Patients in 2018 Versus 2013

Alice Y Guh et al. Open Forum Infect Dis. 2022.

. 2022 Aug 17;9(9):ofac422.

doi: 10.1093/ofid/ofac422. eCollection 2022 Sep.

Authors

Affiliations

¹ Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
² Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California, USA.
³ California Emerging Infections Program, Oakland, California, USA.
⁴ Colorado Department of Public Health and Environment, Denver, Colorado, USA.
⁵ Connecticut Emerging Infections Program, Yale School of Public Health, New Haven, Connecticut, USA.
⁶ Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
⁷ Department of Emergency Health Services, University of Maryland Baltimore County, Baltimore, Maryland, USA.
⁸ Maryland Department of Health, Baltimore, Maryland, USA.
⁹ Minnesota Department of Health, St. Paul, Minnesota, USA.
¹⁰ Career Epidemiology Field Officer Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
¹¹ New Mexico Emerging Infections Program, University of New Mexico, Albuquerque, New Mexico, USA.
¹² Department of Medicine, New York Emerging Infections Program and University of Rochester Medical Center, Rochester, New York, USA.
¹³ Oregon Health Authority, Portland, Oregon, USA.
¹⁴ Tennessee Department of Health, Nashville, Tennessee, USA.
¹⁵ Departments of Medicine and Research, Edward Hines, Jr. Veterans Affairs Hospital, Hines, Illinois, USA.

PMID: 36072699
PMCID: PMC9439575
DOI: 10.1093/ofid/ofac422

Abstract

Among persons with an initial Clostridioides difficile infection (CDI) across 10 US sites in 2018 compared with 2013, 18.3% versus 21.1% had ≥1 recurrent CDI (rCDI) within 180 days. We observed a 16% lower adjusted risk of rCDI in 2018 versus 2013 (P < .0001).

Keywords: Clostridioides difficile; infection; recurrent.

Published by Oxford University Press on behalf of Infectious Diseases Society of America 2022.

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References

1. Olsen MA, Yan Y, Reske KA, Zilberberg MD, Dubberke ER. Recurrent Clostridium difficile infection is associated with increased mortality. Clin Microbiol Infect 2015; 21:164–70. - PubMed
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Comparison of the Risk of Recurrent Clostridioides Difficile Infections Among Patients in 2018 Versus 2013

Affiliations

Comparison of the Risk of Recurrent Clostridioides Difficile Infections Among Patients in 2018 Versus 2013

Authors

Affiliations

Abstract

References

Grants and funding

LinkOut - more resources

Full Text Sources