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Review
. 2022 Aug 22:9:959285.
doi: 10.3389/fcvm.2022.959285. eCollection 2022.

Hypertension as a risk factor for atherosclerosis: Cardiovascular risk assessment

Anastasia V Poznyak  1 , Nikolay K Sadykhov  2 , Andrey G Kartuesov  3 , Evgeny E Borisov  2 , Alexandra A Melnichenko  3 , Andrey V Grechko  4 , Alexander N Orekhov  1   2   3
Affiliations
Review

Hypertension as a risk factor for atherosclerosis: Cardiovascular risk assessment

Anastasia V Poznyak et al. Front Cardiovasc Med. .

Abstract

Atherosclerosis is a predecessor of numerous cardiovascular diseases (CVD), which often lead to morbidity and mortality. Despite the knowledge of the pathogenesis of atherosclerosis, an essential gap in our understanding is the exact trigger mechanism. A wide range of risk factors have been discovered; however, a majority of them are too general to clarify the launching mechanism of atherogenesis. Some risk factors are permanent (age, gender, genetic heritage) and others can be modified [tobacco smoking, physical inactivity, poor nutrition, high blood pressure, type 2 diabetes (T2D), dyslipidemia, and obesity]. All of them have to be taken into account. In the scope of this review, our attention is focused on hypertension, which is considered the most widespread among all modifiable risk factors for atherosclerosis development. Moreover, high blood pressure is the most investigated risk factor. The purpose of this review is to summarize the data on hypertension as a risk factor for atherosclerosis development and the risk assessment.

Keywords: atherosclerosis; cardiovascular disease; cardiovascular risk; hypertension; vessels.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer AM declared a shared affiliation with the authors EB and AG to the handling editor at the time of review.

Figures

FIGURE 1
FIGURE 1
Risk factors for atherosclerosis development.
See this image and copyright information in PMC

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