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Review
. 2022 Aug-Sep;20(6):251-257.
doi: 10.1089/adt.2022.036. Epub 2022 Sep 8.

A Review on Delivery and Bioavailability Enhancement Strategies of Azithromycin

Pallavi Swarup  1 , Gopal Prasad Agrawal  2
Affiliations
Review

A Review on Delivery and Bioavailability Enhancement Strategies of Azithromycin

Pallavi Swarup et al. Assay Drug Dev Technol. 2022 Aug-Sep.

Abstract

Azithromycin (AZI) belongs to the class of macrolide antibiotics that has limited water solubility and belongs to Biopharmaceutical Classification System Class II. Dissolution is the rate-limiting step in the absorption process of AZI. Several approaches have been investigated for enhancing the bioavailability of poorly soluble drugs. This review intends to explore the various strategies that have been investigated for improving the solubility and/or bioavailability of AZI and the delivery systems that have been designed for delivery of AZI in ocular fluid.

Keywords: antibiotic; azithromycin; bioavailability; liquisolid; ocular delivery; solid dispersion.

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