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. 2023 Jan;14(1):15-18.
doi: 10.1111/jdi.13902. Epub 2022 Sep 8.

Advances in insulin therapy from discovery to β-cell replacement

Teruaki Sakurai  1   2 , Sodai Kubota  1   2   3 , Takehiro Kato  1   2 , Daisuke Yabe  1   2   3   4   5
Affiliations

Advances in insulin therapy from discovery to β-cell replacement

Teruaki Sakurai et al. J Diabetes Investig. 2023 Jan.

Abstract

Insulin therapy using insulin purified from porcine or bovine pancreas revolutionized diabetes therapy in the 1920s. A series of advances including cloning human insulin cDNA enabled the development of recombinant human insulin with improved features. Insulin treatment for diabetes may well be upended by β-cell replacement therapy in the coming decades.

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Figures

Figure 1
Figure 1
From purified insulin to β‐cell replacement therapy. Insulin therapy using insulin purified from porcine or bovine pancreas revolutionized diabetes therapy in the 1920s. A series of advances including cloning human insulin complementary deoxyribonucleic acid in 1979 enabled the development of recombinant human insulin with improved features. In 2021, Timothy Kieffer and his associates reported that implantation of pancreatic endoderm from pluripotent stem cells (PSCs) can detect meal‐induced C‐peptide secretion in people with type 1 diabetes. Thus, insulin treatment for diabetes may well be upended by β‐cell replacement therapy in the coming decades.
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References

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