The Unified Multiple System Atrophy Rating Scale: Status, Critique, and Recommendations

Florian Krismer¹, Jose-Alberto Palma², Giovanna Calandra-Buonaura^{3

4}, Iva Stankovic⁵, Luca Vignatelli^{3

4}, Anna-Karin Berger⁶, Cristian Falup-Pecurariu⁷, Alexandra Foubert-Samier⁸, Günter Höglinger^{9

10}, Horacio Kaufmann², Larry Kellerman¹¹, Han-Joon Kim¹², Thomas Klockgether^{13

14}, Johannes Levin^{9

15

16

17}, Pablo Martinez-Martin¹⁸, Tiago A Mestre¹⁹, Maria Teresa Pellecchia²⁰, Susan Perlman²¹, Irfan Qureshi²², Olivier Rascol²³, Anette Schrag²⁴, Klaus Seppi¹, Huifang Shang²⁵, Glenn T Stebbins²⁶, Gregor K Wenning¹, Wolfgang Singer²⁷, Wassilios G Meissner^{8

28

29

30}

Affiliations

¹ Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
² Department of Neurology, New York University Grossman School of Medicine, New York, New York, USA.
³ Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
⁴ IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
⁵ Neurology Clinic, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Beograd, Serbia.
⁶ Clinical Science, Assessment and Innovation, Department of Clinical Development, Lundbeck, Valby, Denmark.
⁷ Department of Neurology, County Clinic Hospital, Faculty of Medicine, Transylvania University, Brasov, Romania.
⁸ CHU Bordeaux, Service de Neurologie des Maladies Neurodégénératives, IMNc, Bordeaux, France.
⁹ German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
¹⁰ Department of Neurology, Hannover Medical School, Hannover, Germany.
¹¹ Patient Advocacy Group, Multiple System Atrophy Coalition, McLean, Virginia, USA.
¹² Department of Neurology and Movement Disorder Center, Seoul National University Hospital, Seoul, South Korea.
¹³ Department of Neurology, University Hospital Bonn, Bonn, Germany.
¹⁴ German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
¹⁵ Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.
¹⁶ Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
¹⁷ SME, MODAG GmbH, Wendelsheim, Germany.
¹⁸ Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Carlos III Institute of Health, Madrid, Spain.
¹⁹ Parkinson's Disease and Movement Disorders Center, Division of Neurology, Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa Brain and Mind Institute, Ottawa, Ontario, Canada.
²⁰ Department of Medicine, Surgery and Dentistry, Neuroscience Section, University of Salerno, Salerno, Italy.
²¹ Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
²² Pharmaceutical Company, Biohaven Pharmaceuticals, New Haven, Connecticut, USA.
²³ French Reference Center for MSA, CIC 1436, NS-Park/FCRIN network and NeuroToul COEN Center, University Hospital of Toulouse, University of Toulouse 3 and INSERM, Toulouse, France.
²⁴ Department of Clinical Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
²⁵ Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
²⁶ Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
²⁷ Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
²⁸ University of Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France.
²⁹ Department of Medicine, University of Otago, Christchurch, New Zealand.
³⁰ New Zealand Brain Research Institute, Christchurch, New Zealand.

PMID: 36074648
PMCID: PMC9771866
DOI: 10.1002/mds.29215

The Unified Multiple System Atrophy Rating Scale: Status, Critique, and Recommendations

Florian Krismer et al. Mov Disord. 2022 Dec.

. 2022 Dec;37(12):2336-2341.

doi: 10.1002/mds.29215. Epub 2022 Sep 8.

Authors

Affiliations

¹ Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
² Department of Neurology, New York University Grossman School of Medicine, New York, New York, USA.
³ Dipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
⁴ IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
⁵ Neurology Clinic, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Beograd, Serbia.
⁶ Clinical Science, Assessment and Innovation, Department of Clinical Development, Lundbeck, Valby, Denmark.
⁷ Department of Neurology, County Clinic Hospital, Faculty of Medicine, Transylvania University, Brasov, Romania.
⁸ CHU Bordeaux, Service de Neurologie des Maladies Neurodégénératives, IMNc, Bordeaux, France.
⁹ German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
¹⁰ Department of Neurology, Hannover Medical School, Hannover, Germany.
¹¹ Patient Advocacy Group, Multiple System Atrophy Coalition, McLean, Virginia, USA.
¹² Department of Neurology and Movement Disorder Center, Seoul National University Hospital, Seoul, South Korea.
¹³ Department of Neurology, University Hospital Bonn, Bonn, Germany.
¹⁴ German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
¹⁵ Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.
¹⁶ Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
¹⁷ SME, MODAG GmbH, Wendelsheim, Germany.
¹⁸ Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Carlos III Institute of Health, Madrid, Spain.
¹⁹ Parkinson's Disease and Movement Disorders Center, Division of Neurology, Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa Brain and Mind Institute, Ottawa, Ontario, Canada.
²⁰ Department of Medicine, Surgery and Dentistry, Neuroscience Section, University of Salerno, Salerno, Italy.
²¹ Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
²² Pharmaceutical Company, Biohaven Pharmaceuticals, New Haven, Connecticut, USA.
²³ French Reference Center for MSA, CIC 1436, NS-Park/FCRIN network and NeuroToul COEN Center, University Hospital of Toulouse, University of Toulouse 3 and INSERM, Toulouse, France.
²⁴ Department of Clinical Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
²⁵ Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, West China Hospital, Sichuan University, Chengdu, China.
²⁶ Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
²⁷ Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
²⁸ University of Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France.
²⁹ Department of Medicine, University of Otago, Christchurch, New Zealand.
³⁰ New Zealand Brain Research Institute, Christchurch, New Zealand.

PMID: 36074648
PMCID: PMC9771866
DOI: 10.1002/mds.29215

No abstract available

PubMed Disclaimer

References

1. Wenning GK, Tison F, Seppi K, et al. Development and validation of the unified multiple system atrophy rating scale (UMSARS). Mov Disord 2004;19(12):1391–1402. - PubMed
1. Krismer F, Seppi K, Tison F, et al. The unified multiple system atrophy rating scale: intrarater reliability. Mov Disord 2012;27(13):1683–1685. - PMC - PubMed
1. Wenning GK, Geser F, Krismer F, et al. The natural history of multiple system atrophy: a prospective European cohort study. Lancet Neurol 2013;12(3):264–274. - PMC - PubMed
1. Low PA, Robertson D, Gilman S, et al. Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double‐blind, placebo‐controlled trial. Lancet Neurol 2014;13(3):268–275. - PMC - PubMed
1. Low PA, Reich SG, Jankovic J, et al. Natural history of multiple system atrophy in the USA: a prospective cohort study. Lancet Neurol 2015;14(7):710–719. - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

The Unified Multiple System Atrophy Rating Scale: Status, Critique, and Recommendations

Affiliations

The Unified Multiple System Atrophy Rating Scale: Status, Critique, and Recommendations

Authors

Affiliations

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources