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Case Reports
. 2023 Apr;36(2):232-235.
doi: 10.1177/19714009221126015. Epub 2022 Sep 8.

Pediatric-type diffuse low-grade glioma with MYB/MYBL1 alteration: report of 2 cases

Tuba Kalelioglu  1 , Bharath Rama  1 , Benjamin B Cho  1 , Beatriz M Lopes  1 , Sohil H Patel  1
Affiliations
Case Reports

Pediatric-type diffuse low-grade glioma with MYB/MYBL1 alteration: report of 2 cases

Tuba Kalelioglu et al. Neuroradiol J. 2023 Apr.

Abstract

2016 World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) has shown how molecular features can impact the classification of brain tumors. The continued combination of molecular features with histopathology has led to distinguish tumors with similar histopathologic features but distinct clinical prognosis. The 2021 revised 5. edition of the WHO classification further includes molecular features for CNS tumor categorization including MYB/MYBL1 altered diffuse astrocytoma which is a newly recognized type of low-grade pediatric-type brain tumor. We discuss imaging features of two pediatric-type low-grade gliomas with MYB/MYBL1-mutation that encountered at our institution.

Keywords: MYB; MYBL1; glioma; imaging; pediatric; radiology.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Low-grade glioma, MYB(L1)-family, subtype B. (a) T2WI and (b) FLAIR hyperintense lesion in the right temporo-occipital periventricular white matter(arrow). (c) There was no enhancement on T1W postcontrast image (arrow). (d) Facilitated diffusion seen on DWI (arrow) and (e) ADC map (arrow). (f) Hypoperfusion was seen on rCBV map (arrow).
Figure 2.
Figure 2.
Diffuse astrocytoma, MYB(L1)-family, subtype D. (a) T2 hyperintense and (b) FLAIR hypo-intense. Lesion in right medial temporal lobe with peripheral hyperintense rim on FLAIR. (c) There was no enhancement on postcontrast T1WI. (d) Facilitated diffusion on DWI and (e) ADC map. (f) Hypoperfusion was seen on rCBV map.
See this image and copyright information in PMC

References

    1. Ellison DW, Hawkins C, Jones DTW, et al. cIMPACT-NOW update 4: diffuse gliomas characterized by MYB, MYBL1, or FGFR1 alterations or BRAFV600E mutation. Acta Neuropathol (Berl) 2019; 137(4): 683–687. - PubMed
    1. Louis DN, Perry A, Reifenberger G, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol (Berl) 2016; 131(6): 803–820. - PubMed
    1. Chiang J, Harreld JH, Tinkle CL, et al. A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration. Acta Neuropathol (Berl) 2019; 138(6): 1091–1092. - PMC - PubMed
    1. Johnson DR, Kaufmann TJ, Patel SH, et al. There is an exception to every rule—T2-FLAIR mismatch sign in gliomas. Neuroradiology 2019; 61(2): 225–227. - PubMed
    1. Capper D, Stichel D, Sahm F, et al. Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience. Acta Neuropathol (Berl) 2018; 136(2): 181–210. - PMC - PubMed

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